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Hoarseness or changing voice and drugs of ingredients of horse chestnut - a phase IV clinical study of FDA data


Summary:

Hoarseness or changing voice is found among people who take drugs with ingredients of horse chestnut, especially for people who are female, 60+ old , have been taking the drugs for < 1 month. This phase IV clinical study is created by eHealthMe based on reports of 7,053 people who have side effects when taking drugs with ingredients of horse chestnut from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Aescin, Aesculus hippocastanum, Buckeye, Castaño de indias, Chestnut, Escine, Hippocastani cortex, Hippocastani flos, Hippocastani folium, Hippocastani semen, Hippocastanum vulgare gaertn, Horse chestnut, Marron europeen, Marronnier, Pu, Spanish chestnut, Venastat, Venostasin retard, Venostat, White chestnut.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Mar, 21, 2023

7,053 people reported to have side effects when taking drugs with ingredients of horse chestnut.
Among them, 22 people (0.31%) have Hoarseness or changing voice

What is Hoarseness or changing voice?

Hoarseness or changing voice is found to be associated with 3,022 drugs and 2,492 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of horse chestnut cause Hoarseness or changing voice?

Time on drugs with ingredients of horse chestnut when people have Hoarseness or changing voice *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Hoarseness or changing voice when taking drugs with ingredients of horse chestnut *:

  • female: 63.64 %
  • male: 36.36 %

Age of people who have Hoarseness or changing voice when taking drugs with ingredients of horse chestnut *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 5.26 %
  • 50-59: 10.53 %
  • 60+: 84.21 %

Conditions people have *:

  1. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 18.18%
  2. Parkinson's Disease: 3 people, 13.64%
  3. Pain: 3 people, 13.64%
  4. Sleep Disorder: 2 people, 9.09%
  5. Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 2 people, 9.09%
  6. Neuralgia (pain in one or more nerves): 2 people, 9.09%
  7. Tumor Pain: 1 person, 4.55%
  8. Hallucinations (sensations that appear real but are created by your mind): 1 person, 4.55%
  9. Agitation (state of anxiety or nervous excitement): 1 person, 4.55%
  10. Arrhythmias (irregular heartbeat): 1 person, 4.55%

Other drugs people take *:

  1. Lasix: 5 people, 22.73%
  2. Neurontin: 5 people, 22.73%
  3. Imdur: 5 people, 22.73%
  4. Vitamin D3: 5 people, 22.73%
  5. Zyrtec: 4 people, 18.18%
  6. Synthroid: 4 people, 18.18%
  7. Opsumit: 4 people, 18.18%
  8. Klonopin: 4 people, 18.18%
  9. Zetia: 4 people, 18.18%
  10. Aldactone: 3 people, 13.64%

Other side effects people have besides Hoarseness or changing voice *:

  1. Pain: 7 people, 31.82%
  2. Memory Loss: 6 people, 27.27%
  3. Productive Cough: 5 people, 22.73%
  4. Fever: 5 people, 22.73%
  5. Headache (pain in head): 5 people, 22.73%
  6. Insomnia (sleeplessness): 5 people, 22.73%
  7. Cough: 5 people, 22.73%
  8. Fatigue (feeling of tiredness): 5 people, 22.73%
  9. Rhinorrhea (watery mucus discharge from the nose): 4 people, 18.18%
  10. Swallowing Difficulty: 4 people, 18.18%

* Approximation only. Some reports may have incomplete information.

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

How the study uses the data?

The study uses data from the FDA. It is based on horse chestnut. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

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DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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