Gastrointestinal inflammation and drugs of ingredients of isotretinoin - a phase IV clinical study of FDA data


Gastrointestinal inflammation is found among people who take drugs with ingredients of isotretinoin, especially for people who are female, 10-19 old , have been taking the drugs for 1 - 6 months. This phase IV clinical study is created by eHealthMe based on reports of 64,360 people who have side effects when taking drugs with ingredients of isotretinoin from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Absorica, Absorica ld, Accutane, Amnesteem, Claravis, Isotretinoin, Myorisan, Sotret, Zenatane.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Aug, 18, 2022

64,360 people reported to have side effects when taking drugs with ingredients of isotretinoin.
Among them, 22 people (0.03%) have Gastrointestinal inflammation

What is Gastrointestinal inflammation?

Gastrointestinal inflammation (inflammation of stomach and intestine) is found to be associated with 774 drugs and 512 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of isotretinoin cause Gastrointestinal inflammation?

Time on drugs with ingredients of isotretinoin when people have Gastrointestinal inflammation *:

  • < 1 month: 11.11 %
  • 1 - 6 months: 83.33 %
  • 6 - 12 months: 5.5600000000000005 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Gastrointestinal inflammation when taking drugs with ingredients of isotretinoin *:

  • female: 54.55 %
  • male: 45.45 %

Age of people who have Gastrointestinal inflammation when taking drugs with ingredients of isotretinoin *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 57.89 %
  • 20-29: 21.05 %
  • 30-39: 5.26 %
  • 40-49: 0.0 %
  • 50-59: 15.79 %
  • 60+: 0.0 %

Conditions people have *:

  1. Skin Disorder (skin disease): 1 person, 4.55%
  2. Pain: 1 person, 4.55%
  3. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 4.55%
  4. Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 4.55%
  5. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 1 person, 4.55%
  6. Birth Control: 1 person, 4.55%

Other drugs people take *:

  1. Retin-A: 2 people, 9.09%
  2. Monistat: 2 people, 9.09%
  3. Differin: 2 people, 9.09%
  4. Desogen: 2 people, 9.09%
  5. Valproate Sodium: 1 person, 4.55%
  6. Tysabri: 1 person, 4.55%
  7. Ortho Cyclen-28: 1 person, 4.55%
  8. Naproxen: 1 person, 4.55%
  9. Humira: 1 person, 4.55%

Other side effects people have besides Gastrointestinal inflammation *:

  1. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 12 people, 54.55%
  2. Inflammatory Bowel Disease: 12 people, 54.55%
  3. Depression: 9 people, 40.91%
  4. Irritable Bowel Syndrome: 8 people, 36.36%
  5. Intestinal Haemorrhage (bleeding from intestine): 8 people, 36.36%
  6. Nosebleed (bleeding from nose): 7 people, 31.82%
  7. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 6 people, 27.27%
  8. Headache (pain in head): 6 people, 27.27%
  9. Stress And Anxiety: 5 people, 22.73%
  10. Rectal Haemorrhage (bleeding from anus): 5 people, 22.73%

* Approximation only. Some reports may have incomplete information.

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Drugs with ingredients of isotretinoin, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on isotretinoin. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


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DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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