Gastrointestinal inflammation and drugs of ingredients of ketorolac tromethamine - a phase IV clinical study of FDA data


Summary:

Gastrointestinal inflammation is found among people who take drugs with ingredients of ketorolac tromethamine, especially for people who are male, 10-19 old , have been taking the drugs for < 1 month. This phase IV clinical study is created by eHealthMe based on reports of 22,334 people who have side effects when taking drugs with ingredients of ketorolac tromethamine from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Acular, Acular ls, Acular preservative free, Acuvail, Ketorolac tromethamine, Sprix, Toradol.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.


On Oct, 03, 2022

22,334 people reported to have side effects when taking drugs with ingredients of ketorolac tromethamine.
Among them, 19 people (0.09%) have Gastrointestinal inflammation


What is Gastrointestinal inflammation?

Gastrointestinal inflammation (inflammation of stomach and intestine) is found to be associated with 823 drugs and 517 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of ketorolac tromethamine cause Gastrointestinal inflammation?

Time on drugs with ingredients of ketorolac tromethamine when people have Gastrointestinal inflammation *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Gastrointestinal inflammation when taking drugs with ingredients of ketorolac tromethamine *:

  • female: 35.71 %
  • male: 64.29 %

Age of people who have Gastrointestinal inflammation when taking drugs with ingredients of ketorolac tromethamine *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 42.86 %
  • 20-29: 14.29 %
  • 30-39: 14.29 %
  • 40-49: 7.14 %
  • 50-59: 7.14 %
  • 60+: 14.29 %

Conditions people have *:

  1. Tumor Necrosis Factor Receptor-Associated Periodic Syndrome: 6 people, 31.58%
  2. Type 1 Diabetes: 4 people, 21.05%
  3. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 21.05%
  4. High Blood Pressure: 4 people, 21.05%
  5. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 3 people, 15.79%
  6. Primary Immunodeficiency Syndrome: 2 people, 10.53%
  7. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 5.26%
  8. Neuromyopathy (disease of both muscles and nerves): 1 person, 5.26%
  9. Magnesium Deficiency (lack of magnesium): 1 person, 5.26%
  10. Hepatitis C: 1 person, 5.26%

Other drugs people take *:

  1. Ondansetron: 8 people, 42.11%
  2. Tylenol: 7 people, 36.84%
  3. Benadryl: 6 people, 31.58%
  4. Gravol: 6 people, 31.58%
  5. Ilaris: 6 people, 31.58%
  6. Synthroid: 5 people, 26.32%
  7. Acetaminophen: 4 people, 21.05%
  8. Vitamin B: 4 people, 21.05%
  9. Vancomycin: 4 people, 21.05%
  10. Valcyte: 4 people, 21.05%

Other side effects people have besides Gastrointestinal inflammation *:

  1. Hypotension (abnormally low blood pressure): 7 people, 36.84%
  2. Nausea (feeling of having an urge to vomit): 7 people, 36.84%
  3. Drug Ineffective: 7 people, 36.84%
  4. Fatigue (feeling of tiredness): 6 people, 31.58%
  5. Joint Injury: 6 people, 31.58%
  6. Tumor Necrosis Factor Receptor-Associated Periodic Syndrome: 6 people, 31.58%
  7. Thirst: 6 people, 31.58%
  8. Ear Pain: 6 people, 31.58%
  9. Post Procedural Oedema (excessive build-up of fluid in the body's tissues after procedure): 6 people, 31.58%
  10. Fever: 6 people, 31.58%

* Approximation only. Some reports may have incomplete information.


How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

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How the study uses the data?

The study uses data from the FDA. It is based on ketorolac tromethamine. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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