Dupuytren's contracture and drugs of ingredients of leflunomide - a phase IV clinical study of FDA data


Dupuytren's contracture is found among people who take drugs with ingredients of leflunomide, especially for people who are female, 60+ old . This phase IV clinical study is created by eHealthMe based on reports of 122,592 people who have side effects when taking drugs with ingredients of leflunomide from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Arava, Leflunomide.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On Aug, 09, 2022

122,592 people reported to have side effects when taking drugs with ingredients of leflunomide.
Among them, 11 people (0.01%) have Dupuytren's contracture

What is Dupuytren's contracture?

Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 443 drugs and 204 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of leflunomide cause Dupuytren's contracture?

Gender of people who have Dupuytren's contracture when taking drugs with ingredients of leflunomide *:

  • female: 72.73 %
  • male: 27.27 %

Age of people who have Dupuytren's contracture when taking drugs with ingredients of leflunomide *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 16.67 %
  • 50-59: 16.67 %
  • 60+: 66.67 %

Conditions people have *:

  1. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 18.18%
  2. Pain: 2 people, 18.18%
  3. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 9.09%
  4. Herpes Virus Infection: 1 person, 9.09%
  5. Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 9.09%

Other drugs people take *:

  1. Humira: 5 people, 45.45%
  2. Enbrel: 4 people, 36.36%
  3. Cosentyx: 3 people, 27.27%
  4. Actemra: 2 people, 18.18%
  5. Simponi: 2 people, 18.18%
  6. Selenium: 2 people, 18.18%
  7. Cimzia: 2 people, 18.18%
  8. Imuran: 2 people, 18.18%
  9. Xeljanz: 2 people, 18.18%
  10. Flaxseed: 2 people, 18.18%

Other side effects people have besides Dupuytren's contracture *:

  1. Back Pain: 6 people, 54.55%
  2. Nausea (feeling of having an urge to vomit): 5 people, 45.45%
  3. Drug Intolerance (drug sensitivity): 3 people, 27.27%
  4. Glycosylated Haemoglobin Increased: 3 people, 27.27%
  5. Dactylitis (dactylitis or sausage digit is inflammation of an entire digit (a finger or toe), and can be painful): 3 people, 27.27%
  6. Iron Binding Capacity Total Decreased: 3 people, 27.27%
  7. Joint Ankylosis (a stiffness of a joint due to abnormal adhesion and rigidity of the bones of the joint): 3 people, 27.27%
  8. Joint Pain: 3 people, 27.27%
  9. Joint Swelling: 3 people, 27.27%
  10. Dizziness: 3 people, 27.27%

* Approximation only. Some reports may have incomplete information.

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Drugs with ingredients of leflunomide, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on leflunomide. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: