Erosive duodenitis and drugs of ingredients of morphine sulfate - a phase IV clinical study of FDA data


Erosive duodenitis is found among people who take drugs with ingredients of morphine sulfate, especially for people who are male, 60+ old , have been taking the drugs for < 1 month. This phase IV clinical study is created by eHealthMe based on reports of 226,404 people who have side effects when taking drugs with ingredients of morphine sulfate from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Arymo er, Astramorph pf, Avinza, Depodur, Duramorph, Duramorph pf, Infumorph, Kadian, Mitigo, Morphabond, Morphabond er, Morphine, Morphine sulfate, Ms contin, Oramorph sr, Roxanol.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Nov, 24, 2022

226,404 people reported to have side effects when taking drugs with ingredients of morphine sulfate.
Among them, 18 people (0.01%) have Erosive duodenitis

What is Erosive duodenitis?

Erosive duodenitis (condition that affects the wall of the small intestine) is found to be associated with 470 drugs and 268 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of morphine sulfate cause Erosive duodenitis?

Time on drugs with ingredients of morphine sulfate when people have Erosive duodenitis *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Erosive duodenitis when taking drugs with ingredients of morphine sulfate *:

  • female: 11.11 %
  • male: 88.89 %

Age of people who have Erosive duodenitis when taking drugs with ingredients of morphine sulfate *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 18.75 %
  • 50-59: 12.5 %
  • 60+: 68.75 %

Conditions people have *:

  1. Pulmonary Embolism (blockage of the main artery of the lung): 7 people, 38.89%
  2. Peripheral Arterial Occlusive Disease (reproducible ischemic muscle pain): 7 people, 38.89%
  3. Coronary Heart Disease (narrowing or blockage of the coronary arteries): 7 people, 38.89%
  4. Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 7 people, 38.89%
  5. Pulmonary Thrombosis (scarring in the lungs): 7 people, 38.89%
  6. Abdominal Pain: 3 people, 16.67%
  7. Embolism Venous (embolus may pass into the arterial system): 3 people, 16.67%
  8. High Blood Cholesterol: 2 people, 11.11%
  9. Breakthrough Pain: 2 people, 11.11%
  10. Breast Cancer Metastatic: 2 people, 11.11%

Other drugs people take *:

  1. Lyrica: 9 people, 50.00%
  2. Norvasc: 7 people, 38.89%
  3. Xarelto: 7 people, 38.89%
  4. Pantoprazole: 7 people, 38.89%
  5. Percocet: 7 people, 38.89%
  6. Lipidil: 4 people, 22.22%
  7. Lovenox: 4 people, 22.22%
  8. Zaroxolyn: 4 people, 22.22%
  9. Lipitor: 4 people, 22.22%
  10. Lomotil: 4 people, 22.22%

Other side effects people have besides Erosive duodenitis *:

  1. Upper Gastrointestinal Haemorrhage (upper gastrointestinal bleeding): 9 people, 50.00%
  2. Rectal Haemorrhage (bleeding from anus): 7 people, 38.89%
  3. Arteriovenous Malformation: 7 people, 38.89%
  4. Nausea (feeling of having an urge to vomit): 7 people, 38.89%
  5. Haemorrhagic Anaemia (anaemia due to excessive bleeding): 7 people, 38.89%
  6. Abdominal Pain: 6 people, 33.33%
  7. Lymphoedema (localized fluid retention and tissue swelling): 6 people, 33.33%
  8. Gastritis Erosive (a break in the surface layer of the membrane lining the stomach with infection): 5 people, 27.78%
  9. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 22.22%
  10. Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 4 people, 22.22%

* Approximation only. Some reports may have incomplete information.

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

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Drugs with ingredients of morphine sulfate, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on morphine sulfate. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


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DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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