Parkinson's disease and drugs of ingredients of nebivolol hydrochloride - a phase IV clinical study of FDA data


Summary:

Parkinson's disease is found among people who take drugs with ingredients of nebivolol hydrochloride, especially for people who are female, 60+ old , have been taking the drugs for 1 - 6 months. This phase IV clinical study is created by eHealthMe based on reports of 32,750 people who have side effects when taking drugs with ingredients of nebivolol hydrochloride from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Bystolic, Nebivolol hydrochloride.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.


On Feb, 07, 2023

32,750 people reported to have side effects when taking drugs with ingredients of nebivolol hydrochloride.
Among them, 42 people (0.13%) have Parkinson's disease


What is Parkinson's disease?

Parkinson's disease is found to be associated with 2,130 drugs and 1,508 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of nebivolol hydrochloride cause Parkinson's disease?

Time on drugs with ingredients of nebivolol hydrochloride when people have Parkinson's disease *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 66.67 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 33.33 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Parkinson's disease when taking drugs with ingredients of nebivolol hydrochloride *:

  • female: 57.14 %
  • male: 42.86 %

Age of people who have Parkinson's disease when taking drugs with ingredients of nebivolol hydrochloride *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 6.45 %
  • 50-59: 0.0 %
  • 60+: 93.55 %

Conditions people have *:

  1. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 9.52%
  2. Hallucinations (sensations that appear real but are created by your mind): 2 people, 4.76%
  3. Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 4.76%
  4. Multiple Myeloma (cancer of the plasma cells): 2 people, 4.76%
  5. Delusion (a false belief or opinion): 2 people, 4.76%
  6. Heart Palpitations (feelings or sensations that your heart is pounding or racing): 1 person, 2.38%
  7. Gastric Disorder (disease of stomach): 1 person, 2.38%
  8. Enlarged Prostate: 1 person, 2.38%
  9. Ear Disorder: 1 person, 2.38%
  10. Dry Mouth: 1 person, 2.38%

Other drugs people take *:

  1. Sinemet: 11 people, 26.19%
  2. Amlodipine: 9 people, 21.43%
  3. Omeprazole: 7 people, 16.67%
  4. Aspirin: 5 people, 11.90%
  5. Vitamin B12: 5 people, 11.90%
  6. Captopril: 5 people, 11.90%
  7. Alprazolam: 5 people, 11.90%
  8. Augmentin '125': 4 people, 9.52%
  9. Diovan: 4 people, 9.52%
  10. Captopril And Hydrochlorothiazide: 4 people, 9.52%

Other side effects people have besides Parkinson's disease *:

  1. Weakness: 10 people, 23.81%
  2. Tremor (trembling or shaking movements in one or more parts of your body): 9 people, 21.43%
  3. Muscle Rigidity (muscle stiffness): 8 people, 19.05%
  4. Oedema Peripheral (superficial swelling): 8 people, 19.05%
  5. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 7 people, 16.67%
  6. Fall: 7 people, 16.67%
  7. Muscle Aches (muscle pain): 6 people, 14.29%
  8. Weight Decreased: 5 people, 11.90%
  9. Dyskinesia (abnormality or impairment of voluntary movement): 5 people, 11.90%
  10. Fatigue (feeling of tiredness): 5 people, 11.90%

* Approximation only. Some reports may have incomplete information.


How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

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How the study uses the data?

The study uses data from the FDA. It is based on nebivolol hydrochloride. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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