Lyme disease and drugs of ingredients of pirfenidone - a phase IV clinical study of FDA data


Lyme disease is reported only by a few people who take drugs with ingredients of pirfenidone. This phase IV clinical study analyzes 36,700 people who have side effects while taking drugs with ingredients of pirfenidone from the the FDA. Among them, 3 have Lyme disease. Find out below who they are, when they have Lyme disease and more.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Esbriet, Pirfenidone.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On May, 26, 2023

36,700 people reported to have side effects when taking drugs with ingredients of pirfenidone.
Among them, 3 people (0.01%) have Lyme disease

What is Lyme disease?

Lyme disease (a bacterial infection that is spread to humans by infected ticks) is found to be associated with 1,114 drugs and 596 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of pirfenidone cause Lyme disease?

Gender of people who have Lyme disease when taking drugs with ingredients of pirfenidone *:

  • female: 0.0 %
  • male: 100 %

Age of people who have Lyme disease when taking drugs with ingredients of pirfenidone *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 100 %

Conditions people have *:

  1. Idiopathic Pulmonary Fibrosis (chronic lung disease): 2 people, 66.67%

Other side effects people have besides Lyme disease *:

  1. Taste - Impaired: 2 people, 66.67%
  2. Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 66.67%
  3. Pneumonia: 2 people, 66.67%
  4. Pharyngeal Inflammation: 2 people, 66.67%
  5. Memory Loss: 2 people, 66.67%
  6. Malaise (a feeling of general discomfort or uneasiness): 2 people, 66.67%
  7. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 66.67%
  8. Fever: 2 people, 66.67%
  9. Fatigue (feeling of tiredness): 2 people, 66.67%
  10. Depression: 2 people, 66.67%

* Approximation only. Some reports may have incomplete information.

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

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How the study uses the data?

The study uses data from the FDA. It is based on pirfenidone. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


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DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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