Perforation bile duct and drugs of ingredients of sulfamethoxazole; trimethoprim - a phase IV clinical study of FDA data


Summary:

Perforation bile duct is found among people who take drugs with ingredients of sulfamethoxazole; trimethoprim, especially for people who are male, 30-39 old . This phase IV clinical study is created by eHealthMe based on reports of 146,610 people who have side effects when taking drugs with ingredients of sulfamethoxazole; trimethoprim from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Bactrim, Bactrim ds, Bactrim pediatric, Cotrim, Cotrim d.s., Septra, Septra ds, Septra grape, Sulfamethoprim, Sulfamethoprim-ds, Sulfamethoxazole and trimethoprim, Sulfamethoxazole and trimethoprim double strength, Sulfamethoxazole and trimethoprim single strength, Sulfatrim, Sulfatrim pediatric, Sulfatrim-ds, Sulfatrim-ss, Sulmeprim, Sulmeprim pediatric, Trimeth/sulfa, Uroplus ds, Uroplus ss.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.


On Nov, 28, 2022

146,610 people reported to have side effects when taking drugs with ingredients of sulfamethoxazole; trimethoprim.
Among them, 6 people (0.0%) have Perforation bile duct


What is Perforation bile duct?

Perforation bile duct (hole in the bowel wall) is found to be associated with 126 drugs and 62 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of sulfamethoxazole; trimethoprim cause Perforation bile duct?

Gender of people who have Perforation bile duct when taking drugs with ingredients of sulfamethoxazole; trimethoprim *:

  • female: 0.0 %
  • male: 100 %

Age of people who have Perforation bile duct when taking drugs with ingredients of sulfamethoxazole; trimethoprim *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 100 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

Conditions people have *:

  1. Herpes Zoster: 6 people, 100.00%
  2. Depression: 6 people, 100.00%
  3. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 6 people, 100.00%
  4. Cholangitis (infection of the bile duct): 6 people, 100.00%
  5. Procedural Pain: 4 people, 66.67%

Other drugs people take *:

  1. Valacyclovir: 6 people, 100.00%
  2. Neurontin: 6 people, 100.00%
  3. Lyrica: 6 people, 100.00%
  4. Innohep: 6 people, 100.00%
  5. Coumadin: 6 people, 100.00%
  6. Vitamin D: 2 people, 33.33%
  7. Tacrolimus: 2 people, 33.33%
  8. Prednisone: 2 people, 33.33%
  9. Nystatin: 2 people, 33.33%
  10. Mycophenolic Acid: 2 people, 33.33%

Other side effects people have besides Perforation bile duct *:

  1. Procedural Complication: 6 people, 100.00%
  2. Post Procedural Infection: 6 people, 100.00%
  3. Liver Transplant Rejection (failure of liver transplant): 6 people, 100.00%
  4. Gastrointestinal Perforation (hole in the digestive tract): 6 people, 100.00%
  5. Escherichia Bacteraemia (presence of bacteria escherichia coli in the blood): 6 people, 100.00%
  6. Cholangitis (infection of the bile duct): 6 people, 100.00%
  7. Bile Duct Stenosis (abnormal narrowing of the common bile duct): 6 people, 100.00%
  8. Hepatic Enzyme Increased: 5 people, 83.33%
  9. Gastrointestinal Pain: 4 people, 66.67%
  10. Pain: 2 people, 33.33%

* Approximation only. Some reports may have incomplete information.


How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

How the study uses the data?

The study uses data from the FDA. It is based on sulfamethoxazole; trimethoprim. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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