Hypotension and drugs of ingredients of tocopherols and tocotrienols - a phase IV clinical study of FDA data


Summary:

Hypotension is found among people who take drugs with ingredients of tocopherols and tocotrienols, especially for people who are female, 60+ old , have been taking the drugs for 5 - 10 years. This phase IV clinical study is created by eHealthMe based on reports of 37,202 people who have side effects when taking drugs with ingredients of tocopherols and tocotrienols from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Vitamin e.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.


On Feb, 06, 2023

37,202 people reported to have side effects when taking drugs with ingredients of tocopherols and tocotrienols.
Among them, 911 people (2.45%) have Hypotension


What is Hypotension?

Hypotension (abnormally low blood pressure) is found to be associated with 4,171 drugs and 4,567 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of tocopherols and tocotrienols cause Hypotension?

Time on drugs with ingredients of tocopherols and tocotrienols when people have Hypotension *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 100 %
  • 10+ years: 0.0 %

Gender of people who have Hypotension when taking drugs with ingredients of tocopherols and tocotrienols *:

  • female: 55.68 %
  • male: 44.32 %

Age of people who have Hypotension when taking drugs with ingredients of tocopherols and tocotrienols *:

  • 0-1: 0.0 %
  • 2-9: 0.13 %
  • 10-19: 0.4 %
  • 20-29: 0.8 %
  • 30-39: 2.66 %
  • 40-49: 4.79 %
  • 50-59: 20.35 %
  • 60+: 70.88 %

Conditions people have *:

  1. High Blood Pressure: 57 people, 6.26%
  2. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 43 people, 4.72%
  3. Multiple Myeloma (cancer of the plasma cells): 39 people, 4.28%
  4. Pain: 33 people, 3.62%
  5. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 25 people, 2.74%
  6. High Blood Cholesterol: 25 people, 2.74%
  7. Depression: 24 people, 2.63%
  8. Osteoporosis (bones weak and more likely to break): 22 people, 2.41%
  9. Stress And Anxiety: 22 people, 2.41%
  10. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 22 people, 2.41%

Other drugs people take *:

  1. Synthroid: 140 people, 15.37%
  2. Vitamin C: 114 people, 12.51%
  3. Lipitor: 112 people, 12.29%
  4. Aspirin: 109 people, 11.96%
  5. Prevacid: 91 people, 9.99%
  6. Vitamin D: 90 people, 9.88%
  7. Lasix: 90 people, 9.88%
  8. Calcium: 86 people, 9.44%
  9. Vitamin D3: 85 people, 9.33%
  10. Folic Acid: 82 people, 9.00%

Other side effects people have besides Hypotension *:

  1. Fatigue (feeling of tiredness): 233 people, 25.58%
  2. Nausea (feeling of having an urge to vomit): 215 people, 23.60%
  3. Dizziness: 201 people, 22.06%
  4. Weakness: 172 people, 18.88%
  5. Fainting (loss of consciousness and postural tone): 158 people, 17.34%
  6. Pain: 137 people, 15.04%
  7. Breathing Difficulty: 111 people, 12.18%
  8. Cough: 110 people, 12.07%
  9. Joint Pain: 104 people, 11.42%
  10. Fall: 103 people, 11.31%

* Approximation only. Some reports may have incomplete information.


How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Drugs with ingredients of tocopherols and tocotrienols, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on tocopherols and tocotrienols. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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