Dupuytren's contracture and drugs of ingredients of verapamil hydrochloride - a phase IV clinical study of FDA data


Summary:

Dupuytren's contracture is reported only by a few people who take drugs with ingredients of verapamil hydrochloride. This phase IV clinical study analyzes 60,363 people who have side effects while taking drugs with ingredients of verapamil hydrochloride from the the FDA. Among them, 5 have Dupuytren's contracture. Find out below who they are, when they have Dupuytren's contracture and more.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Calan, Calan sr, Covera-hs, Isoptin, Isoptin sr, Verapamil hcl, Verapamil hydrochloride, Verelan, Verelan pm.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.


On Sep, 30, 2022

60,363 people reported to have side effects when taking drugs with ingredients of verapamil hydrochloride.
Among them, 5 people (0.01%) have Dupuytren's contracture


What is Dupuytren's contracture?

Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 460 drugs and 212 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of verapamil hydrochloride cause Dupuytren's contracture?

Gender of people who have Dupuytren's contracture when taking drugs with ingredients of verapamil hydrochloride *:

  • female: 80 %
  • male: 20 %

Age of people who have Dupuytren's contracture when taking drugs with ingredients of verapamil hydrochloride *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 80 %
  • 60+: 20 %

Conditions people have *:

  1. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 3 people, 60.00%
  2. Asthma: 3 people, 60.00%
  3. Sleep Disorder: 1 person, 20.00%
  4. Pain: 1 person, 20.00%
  5. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 1 person, 20.00%
  6. Gastric Ulcer (stomach ulcer): 1 person, 20.00%
  7. Dyslipidaemia (abnormal amount of lipids): 1 person, 20.00%
  8. Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 20.00%
  9. Affective Disorder (mental disorder): 1 person, 20.00%

Other drugs people take *:

  1. Singulair: 3 people, 60.00%
  2. Formoterol Fumarate: 3 people, 60.00%
  3. Budesonide: 3 people, 60.00%
  4. Albuterol Sulfate: 3 people, 60.00%
  5. Zopiclone: 1 person, 20.00%
  6. Zestril: 1 person, 20.00%
  7. Vioxx: 1 person, 20.00%
  8. Pepcid: 1 person, 20.00%
  9. Panadol: 1 person, 20.00%
  10. Oxycodone: 1 person, 20.00%

Other side effects people have besides Dupuytren's contracture *:

  1. Burning Sensation: 4 people, 80.00%
  2. Allergic Granulomatous Angiitis (allergic inflammation of a blood vessel or lymph duct): 3 people, 60.00%
  3. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 3 people, 60.00%
  4. Hallucinations (sensations that appear real but are created by your mind): 2 people, 40.00%
  5. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 40.00%
  6. Confusion: 2 people, 40.00%
  7. Drug Intolerance (drug sensitivity): 2 people, 40.00%
  8. Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 2 people, 40.00%
  9. Pain In Extremity: 2 people, 40.00%
  10. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 1 person, 20.00%

* Approximation only. Some reports may have incomplete information.


How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Drugs with ingredients of verapamil hydrochloride, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on verapamil hydrochloride. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

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