Dupuytren's contracture and drugs of ingredients of zafirlukast - a phase IV clinical study of FDA data


Summary:

Dupuytren's contracture is reported only by a few people who take drugs with ingredients of zafirlukast. This phase IV clinical study analyzes 4,973 people who have side effects while taking drugs with ingredients of zafirlukast from the the FDA. Among them, 3 have Dupuytren's contracture. Find out below who they are, when they have Dupuytren's contracture and more.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Accolate, Zafirlukast.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.


On Aug, 09, 2022

4,973 people reported to have side effects when taking drugs with ingredients of zafirlukast.
Among them, 3 people (0.06%) have Dupuytren's contracture


What is Dupuytren's contracture?

Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 443 drugs and 204 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of zafirlukast cause Dupuytren's contracture?

Gender of people who have Dupuytren's contracture when taking drugs with ingredients of zafirlukast *:

  • female: 0.0 %
  • male: 100 %

Conditions people have *:

  1. Osteoporosis (bones weak and more likely to break): 3 people, 100.00%

Other drugs people take *:

  1. Vicodin: 3 people, 100.00%
  2. Ventolin: 3 people, 100.00%
  3. Vasotec: 3 people, 100.00%
  4. Proventil: 3 people, 100.00%
  5. Mevacor: 3 people, 100.00%
  6. Meticorten: 3 people, 100.00%
  7. Fosamax: 3 people, 100.00%
  8. Azmacort: 3 people, 100.00%
  9. Fosamax Plus D: 2 people, 66.67%
  10. Advair Hfa: 2 people, 66.67%

Other side effects people have besides Dupuytren's contracture *:

  1. Joint Dislocation (a joint position is changed from normal position): 3 people, 100.00%
  2. Fall: 3 people, 100.00%
  3. Joint Pain: 3 people, 100.00%
  4. Weight Decreased: 3 people, 100.00%
  5. Impaired Healing: 3 people, 100.00%
  6. Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 3 people, 100.00%
  7. Haemorrhoids (a swollen vein or group of veins in the region of the anus): 3 people, 100.00%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 100.00%
  9. Fracture Nonunion (permanent failure of healing following a broken bone): 3 people, 100.00%
  10. Femur Fracture: 3 people, 100.00%

* Approximation only. Some reports may have incomplete information.


How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Drugs with ingredients of zafirlukast, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on zafirlukast. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

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