Moderna COVID Vaccine and Freezing phenomenon - a phase IV clinical study of CDC and FDA data


Freezing phenomenon is found among people who get Moderna COVID Vaccine, especially for people who are female, 60+ old, and on the same day of getting the vaccine.

The phase IV clinical study analyzes which people get Moderna COVID Vaccine and have Freezing phenomenon. It is created by eHealthMe based on reports of 392,577 people who have side effects when getting Moderna COVID Vaccine from the CDC and the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Apr, 18, 2023

392,577 people reported to have side effects after getting Moderna COVID Vaccine.
Among them, 28 people (0.01%) have Freezing phenomenon.

What is Freezing phenomenon?

Freezing phenomenon is found to be associated with 477 drugs and 212 conditions by eHealthMe.

Number of reports submitted per year:

Moderna covid vaccine and Freezing phenomenon?

Time to have Freezing phenomenon from when people get Moderna COVID Vaccine *:

  • on the same day: 39.13 %
  • in the first week: 26.09 %
  • in the first 30 days: 8.7 %
  • after 30 days: 26.09 %

Gender of people *:

  • female: 64.29 %
  • male: 35.71 %

Age of people *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 8.7 %
  • 50-59: 39.13 %
  • 60+: 52.17 %

Did people recover *:

  • yes: 42.86 %
  • no: 57.14 %

Death as an outcome *:

  • yes: 0.0 %
  • no: 100 %

# of vaccine dose *:

  • 1: 74.07 %
  • 2: 25.93 %
  • 3+: 0.0 %

Common side effects people have besides Freezing phenomenon *:

  1. Chills (felling of cold): 14 people, 50.00%
  2. Muscle Aches (muscle pain): 12 people, 42.86%
  3. Pain: 11 people, 39.29%
  4. Fatigue (feeling of tiredness): 10 people, 35.71%
  5. Hyperhidrosis (abnormally increased sweating): 9 people, 32.14%
  6. Tremor (trembling or shaking movements in one or more parts of your body): 9 people, 32.14%
  7. Nausea (feeling of having an urge to vomit): 9 people, 32.14%
  8. Headache (pain in head): 8 people, 28.57%
  9. Fever: 6 people, 21.43%
  10. Joint Pain: 6 people, 21.43%

* Approximation only. Some reports may have incomplete information.

Related studies

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Vaccine side effects by duration, gender, age and dose:

Common Moderna covid vaccine side effects:

Browse all side effects of Moderna COVID Vaccine:

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How the study uses the data?

The study is based on data from the CDC and the FDA.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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