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How effective is Sam-e for Depressed Mood? (a real world drug study)

Summary:

Overall ratings: 2/5
Long term ratings: 2/5

This is a phase IV clinical study of how effective Sam-e (same) is for Depressed mood and for what kind of people. The study is created by eHealthMe from 3 Sam-e users and is updated continuously.

What is Sam-e?

Sam-e has active ingredients of same. It is often used in depression. eHealthMe is studying from 273 Sam-e users. Check the latest studies of Sam-e.

What is Depressed mood?

Depressed mood is found to be associated with 1,646 drugs and 1,540 conditions by eHealthMe. Check the latest studies of Depressed mood.

On Jul, 05, 2026

3 people are studied for taking Sam-e in Depressed mood

Overall effectiveness (number of people):

Does Sam-e work for your Depressed mood (overall)?

Long term (1+ years) effectiveness (number of people):

Does Sam-e work for your Depressed mood (long term)?

Sam-e effectiveness for Depressed mood (number of people):

Overall:
  • not at all: 1
  • somewhat: 1
  • moderate: 1
  • high: 0
  • very high: 0
Long Term:
  • not at all: 0
  • somewhat: 1
  • moderate: 0
  • high: 0
  • very high: 0

Gender of people who take Sam-e for Depressed mood *:

  • female: 66.67 %
  • male: 33.33 %

Age of people who take Sam-e for Depressed mood *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 33.33 %
  • 40-49: 33.33 %
  • 50-59: 0.0 %
  • 60+: 33.33 %

Who find Sam-e more effective for Depressed Mood?

* Approximation only. Some reports may have incomplete information.

Do you take Sam-e?

- You can start a phase IV clinical trial to monitor Sam-e safety and effectiveness.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Alternative drugs to, pros and cons of:

Treatments, associated drugs and conditions:

How the study uses the data?

The study is based on same (the active ingredients of Sam-e) and Sam-e (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study neither.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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