How effective is Nortriptyline Hydrochloride for Major Depression? (a real world drug study)

Summary:

Overall ratings: 2.5/5
Long term ratings: 2.6/5

This is a phase IV clinical study of how effective Nortriptyline hydrochloride (nortriptyline hydrochloride) is for Major depression and for what kind of people. The study is created by eHealthMe from 11 Nortriptyline hydrochloride users and is updated continuously.

What is Nortriptyline hydrochloride?

Nortriptyline hydrochloride has active ingredients of nortriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 4,817 Nortriptyline hydrochloride users. Check the latest studies of Nortriptyline hydrochloride.

What is Major depression?

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings) is found to be associated with 800 drugs and 1,477 conditions by eHealthMe. Check the latest studies of Major depression.

On Aug, 01, 2026

11 people are studied for taking Nortriptyline hydrochloride in Major depression

Overall effectiveness (number of people):

Does Nortriptyline hydrochloride work for your Major depression (overall)?

Long term (1+ years) effectiveness (number of people):

Does Nortriptyline hydrochloride work for your Major depression (long term)?

Nortriptyline hydrochloride effectiveness for Major depression (number of people):

Overall:

not at all: 3
somewhat: 3
moderate: 1
high: 4
very high: 0

Long Term:

not at all: 2
somewhat: 2
moderate: 0
high: 3
very high: 0

Gender of people who take Nortriptyline hydrochloride for Major depression *:

female: 72.73 %
male: 27.27 %

Age of people who take Nortriptyline hydrochloride for Major depression *:

0-1: 0.0 %
2-9: 0.0 %
10-19: 9.09 %
20-29: 9.09 %
30-39: 27.27 %
40-49: 27.27 %
50-59: 9.09 %
60+: 18.18 %

Who find Nortriptyline Hydrochloride more effective for Major Depression?

Gender of people who take Nortriptyline hydrochloride for Major depression *:

female: 75 %
male: 25 %

Age of people who take Nortriptyline hydrochloride for Major depression *:

0-1: 0.0 %
2-9: 0.0 %
10-19: 0.0 %
20-29: 25 %
30-39: 25 %
40-49: 25 %
50-59: 0.0 %
60+: 25 %

* Approximation only. Some reports may have incomplete information.

Do you take Nortriptyline hydrochloride?

- You can start a phase IV clinical trial to monitor Nortriptyline hydrochloride safety and effectiveness.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Alternative drugs to, pros and cons of:

Nortriptyline hydrochloride (4,817 reports)

Treatments, associated drugs and conditions:

Major depression (44,981 reports)

How the study uses the data?

The study is based on nortriptyline hydrochloride (the active ingredients of Nortriptyline hydrochloride) and Nortriptyline hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study neither.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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