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Anafranil Vs. Effexor for a female patient aged 62 (an AI-powered real world drug study)

Summary:

This is a personalized comparison of Anafranil, Effexor for a woman aged 62. The study is created by eHealthMe based on reports from the FDA and eHealthme.

On Aug, 10, 2026

22,439 females aged 62 (±5) who take Anafranil, Effexor and have adverse effects are studied.

Number of reports submitted per year:

Anafranil, Effexor for a female patient aged 62.

Information of the patient in this study:

  • Age: 62
  • Gender: female

What are the drugs?

  • Anafranil has active ingredients of clomipramine hydrochloride. It is often used in obsessive-compulsive disorder. eHealthMe is studying from 6,304 Anafranil users. Check the latest studies of Anafranil.
  • Effexor has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 99,493 Effexor users. Check the latest studies of Effexor.

What is the reason to compare the drugs?

What are the adverse effects to be compared?

eHealthMe real world results:

Comparison with the specified adverse outcomes (outcome and its % of total reports):

Hot Flashes:

  • Anafranil: 0.01 %
  • Effexor: 0.97 %

Most common side effects:

Anafranil:

  1. Dyspnoea (difficult or laboured respiration)
  2. Drug Ineffective
  3. Pyrexia (fever)
  4. Coma (state of unconsciousness lasting more than six hours)
  5. Somnolence (a state of near-sleep, a strong desire for sleep)
  6. Hypotension (abnormally low blood pressure)
  7. Nausea (feeling of having an urge to vomit)
  8. Suicide Attempt
  9. Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
  10. Cholestasis (a condition where bile cannot flow from the liver to the duodenum)

Effexor:

  1. Drug Ineffective
  2. Nausea (feeling of having an urge to vomit)
  3. Fatigue (feeling of tiredness)
  4. Headache (pain in head)
  5. Pain
  6. Diarrhoea
  7. Dyspnoea (difficult or laboured respiration)
  8. Dizziness
  9. Fall
  10. Malaise (a feeling of general discomfort or uneasiness)

Most common side effects experienced by people in long term (1+ years) use:

Anafranil:

  1. Nervous System Disorder (a general class of medical conditions affecting the nervous system)
  2. Extrasystoles
  3. Heart Rate Irregular
  4. Depressed Mood
  5. Nightmare (unpleasant dream)
  6. Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
  7. Palpitations (feelings or sensations that your heart is pounding or racing)
  8. Disturbance In Sexual Arousal
  9. Emotional Distress
  10. Suicidal Ideation

Effexor:

  1. Drug Ineffective
  2. Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
  3. Headache (pain in head)
  4. Dizziness
  5. Malaise (a feeling of general discomfort or uneasiness)
  6. Nausea (feeling of having an urge to vomit)
  7. Insomnia (sleeplessness)
  8. Fatigue (feeling of tiredness)
  9. Suicidal Ideation
  10. Tremor (trembling or shaking movements in one or more parts of your body)

Drug effectiveness:

Anafranil:

  • not at all: 16.67 %
  • somewhat: 16.67 %
  • moderate: 33.33 %
  • high: 16.67 %
  • very high: 16.67 %

Effexor:

  • not at all: 2.35 %
  • somewhat: 14.82 %
  • moderate: 36.29 %
  • high: 35.32 %
  • very high: 11.22 %


How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

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How the study uses the data?

The study is based on gender, age, active ingredients of any drugs used. Other drugs that have the same active ingredients (e.g. generic drugs) are considered. Dosage of drugs is not considered in the study.

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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