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Quetiapine Fumarate Vs. Amitriptyline Hydrochloride for a female patient aged 61 (an AI-powered real world drug study)

Summary:

This is a personalized comparison of Quetiapine Fumarate, Amitriptyline Hydrochloride for a woman aged 61. The study is created by eHealthMe based on reports from the FDA and eHealthme.

On Aug, 10, 2026

34,066 females aged 61 (±5) who take Quetiapine Fumarate, Amitriptyline Hydrochloride and have adverse effects are studied.

Number of reports submitted per year:

Quetiapine Fumarate, Amitriptyline Hydrochloride for a female patient aged 61.

Information of the patient in this study:

  • Age: 61
  • Gender: female

What are the drugs?

What is the reason to compare the drugs?

What are the adverse effects to be compared?

eHealthMe real world results:

Comparison with the specified adverse outcomes (outcome and its % of total reports):

Anxiety Disorder:

  • Quetiapine Fumarate: 0.06 %
  • Amitriptyline Hydrochloride: 0.07 %

Insomnia (sleeplessness):

  • Quetiapine Fumarate: 3.52 %
  • Amitriptyline Hydrochloride: 2.58 %

Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings):

  • Quetiapine Fumarate: 0.17 %
  • Amitriptyline Hydrochloride: 0.1 %

Most common side effects:

Quetiapine Fumarate:

  1. Drug Ineffective
  2. Fatigue (feeling of tiredness)
  3. Nausea (feeling of having an urge to vomit)
  4. Pain
  5. Headache (pain in head)
  6. Anxiety
  7. Fall
  8. Malaise (a feeling of general discomfort or uneasiness)
  9. Weight Increased
  10. Diarrhoea

Amitriptyline Hydrochloride:

  1. Pain
  2. Nausea (feeling of having an urge to vomit)
  3. Fatigue (feeling of tiredness)
  4. Headache (pain in head)
  5. Drug Ineffective
  6. Diarrhoea
  7. Arthralgia (joint pain)
  8. Dyspnoea (difficult or laboured respiration)
  9. Fall
  10. Dizziness

Most common side effects experienced by people in long term (1+ years) use:

Quetiapine Fumarate:

  1. Diabetes Mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  2. Type 2 Diabetes Mellitus
  3. Weight Increased
  4. Blood Cholesterol Increased
  5. Obesity (having too much body fat)
  6. Fall
  7. Headache (pain in head)
  8. Blood Triglycerides Increased
  9. Anxiety
  10. Dizziness

Amitriptyline Hydrochloride:

  1. Chronic Kidney Disease
  2. Renal Failure (kidney dysfunction)
  3. Pyrexia (fever)
  4. Anxiety
  5. Nephrogenic Anaemia (anaemia due to kidney disease)
  6. Osteonecrosis (death of bone)
  7. Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
  8. Nausea (feeling of having an urge to vomit)
  9. Hyperparathyroidism Secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
  10. Dyspnoea (difficult or laboured respiration)

Drug effectiveness:

Quetiapine Fumarate:

  • not at all: 6.19 %
  • somewhat: 18.89 %
  • moderate: 28.34 %
  • high: 31.27 %
  • very high: 15.31 %

Amitriptyline Hydrochloride:

  • not at all: 2.63 %
  • somewhat: 22.49 %
  • moderate: 34.45 %
  • high: 29.67 %
  • very high: 10.77 %


How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

Related publications that referenced our studies

Related studies

How the study uses the data?

The study is based on gender, age, active ingredients of any drugs used. Other drugs that have the same active ingredients (e.g. generic drugs) are considered. Dosage of drugs is not considered in the study.

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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