Accolate and Demerol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Accolate (zafirlukast) and Demerol (meperidine hydrochloride). Common drug interactions include injury among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Accolate and Demerol. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Accolate?

Accolate has active ingredients of zafirlukast. It is often used in asthma. eHealthMe is studying from 4,220 Accolate users. Check the latest studies of Accolate.

What is Demerol?

Demerol has active ingredients of meperidine hydrochloride. It is often used in pain. eHealthMe is studying from 12,706 Demerol users. Check the latest studies of Demerol.

On Aug, 08, 2026

21 people who take Accolate and Demerol together, and have interactions are studied.

What are the common drug interactions of Accolate and Demerol, by gender? *:

female:

Injury
Localised infection (infection at the single location)
Macrocytosis (enlargement of red blood cells with near-constant haemoglobin concentration)
Mean cell haemoglobin concentration decreased (less concentration of haemoglobin in a given volume of packed red blood cells)
Mean cell volume decreased (less of the average red blood cell volume)
Mean cell volume increased (more than normal average red blood cell volume)
Monocyte count decreased
Nail infection
Pleural fibrosis (formation of fibrous tissue in lung)
Poor peripheral circulation

male:

Abdominal distension
Aortic valve sclerosis (narrowing of the aortic valve)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Diabetes mellitus inadequate control
Diabetic nephropathy (diabetic kidney disease)
Diarrhoea
Diastolic dysfunction
Dilatation ventricular
Emotional disorder
Erosive duodenitis (a condition that affects the wall of the small intestine)

What are the common drug interactions of Accolate and Demerol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cardiac arrest
Ventricular hypertrophy (enlargement of ventricles (lower chambers) in the heart)
Arrhythmia (irregular heartbeat)
Blood potassium decreased
Blood potassium increased
Cardiomegaly (increased size of heart than normal)
Dysphagia (a condition in which swallowing is difficult or painful)
Ventricular arrhythmia (problem with the rate or rhythm of the heartbeat)

40-49:

n/a

50-59:

Exsanguination (process of blood loss, to a degree sufficient to cause death)
Oedema (fluid collection in tissue)
Oesophageal ulcer haemorrhage (bleeding from oesophagus ulcer)
Rib fracture
Large intestinal ulcer nos haemorrhage
Sudden cardiac death
Alanine aminotransferase increased
Arrhythmia (irregular heartbeat)
Cardiac arrest
Chronic obstructive airways disease

60+:

Anger
Fall
Mood swings (an extreme or rapid change in mood)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Peripheral swelling
Psoriasis (immune-mediated disease that affects the skin)
Pyrexia (fever)
Vision blurred

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 2 people, 9.52%
Neck Pain: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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