Accolate and Estrace drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Accolate (zafirlukast) and Estrace (estradiol). Common drug interactions include alopecia among females.

The phase IV clinical study analyzes what interactions people have when they take Accolate and Estrace. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Accolate?

Accolate has active ingredients of zafirlukast. It is often used in asthma. eHealthMe is studying from 4,220 Accolate users. Check the latest studies of Accolate.

What is Estrace?

Estrace has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 16,703 Estrace users. Check the latest studies of Estrace.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

24 people who take Accolate and Estrace together, and have interactions are studied.

What are the common drug interactions of Accolate and Estrace, by gender? *:

female:

Alopecia (absence of hair from areas of the body)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Emotional distress
Eye disorder
Eye pain
Fatigue (feeling of tiredness)
Migraine (headache)
Myalgia (muscle pain)
Osteoporosis (bones weak and more likely to break)
Photosensitivity reaction

male:

n/a

What are the common drug interactions of Accolate and Estrace, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Migraine (headache)
Osteoporosis (bones weak and more likely to break)
Pain
Taste disturbance
Abdominal pain
Alopecia (absence of hair from areas of the body)
Amblyopia (lazy eye)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Conjunctivitis (pink eye)

50-59:

Alopecia (absence of hair from areas of the body)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Hair disorder
Lymphadenopathy (disease or enlargement of lymph nodes)
Norepinephrine increased (excess level of norepinephrine)
Palpitations (feelings or sensations that your heart is pounding or racing)

60+:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Oedema (fluid collection in tissue)
Arthralgia (joint pain)
Bronchial hyperactivity
Bronchitis acute (acute inflammation of the mucous membrane in the bronchial tubes)
Candidiasis (candidiasis or thrush is a fungal infection)
Cardiac disorder
Cardiac murmur (an heart sound in valve abnormality)
Carotid artery occlusion (artery blockage)
Carotid artery thrombosis (blood clot in carotid artery)

What are the existing conditions these people have? *

High Blood Pressure: 4 people, 16.67%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 12.50%
Headache (pain in head): 3 people, 12.50%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 12.50%
Neuralgia (pain in one or more nerves): 2 people, 8.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 8.33%
Hiv Infection: 2 people, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.33%
Depression: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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