Accupril and Actonel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Accupril (quinapril hydrochloride) and Actonel (risedronate sodium). Common drug interactions include anxiety among females and prostatic specific antigen increased among males.

The phase IV clinical study analyzes what interactions people have when they take Accupril and Actonel. It is created by eHealthMe based on reports of 91 people who take the same drugs from the FDA, and is updated regularly.

What is Accupril?

Accupril has active ingredients of quinapril hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 13,404 Accupril users. Check the latest studies of Accupril.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.



On Jul, 11, 2026

91 people who take Accupril and Actonel together, and have interactions are studied.

Accupril and Actonel drug interactions.

What are the common drug interactions of Accupril and Actonel, by gender? *:

female:

  1. Anxiety
  2. Chest pain
  3. Dysuria (painful or difficult urination)
  4. Low turnover osteopathy (slow removal of old bone and its replacement by new bone)
  5. Oedema (fluid collection in tissue)
  6. Weight decreased
  7. Bone disorder
  8. Infection
  9. Osteonecrosis (death of bone)
  10. Periodontitis (inflammation of the tissue around the teeth)

male:

  1. Prostatic specific antigen increased
  2. Back pain
  3. Viral infection
  4. Weight increased
  5. Abasia (inability to walk)
  6. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  7. Blood cholesterol increased
  8. Blood glucose increased
  9. Body height decreased
  10. Cough

What are the common drug interactions of Accupril and Actonel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Dyspnoea (difficult or laboured respiration)
  2. Vomiting
  3. Asthenia (weakness)
  4. Cardiomyopathy (weakening of the heart muscle)
  5. Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
  6. Drug intolerance (drug sensitivity)
  7. Dysgeusia (disorder of the sense of taste)
  8. Ejection fraction decreased (systolic heart failure)
  9. Embolic stroke (stroke due to obstruction due to an embolus)
  10. Feeling cold

50-59:

  1. Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
  2. Drug toxicity
  3. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  4. Hyperlipidaemia (presence of excess lipids in the blood)
  5. Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
  6. Hypoglycaemia (deficiency of glucose in the bloodstream)
  7. Hypokalaemia (low potassium)
  8. Hypotension (abnormally low blood pressure)
  9. Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
  10. Peroneal nerve palsy

60+:

  1. Face oedema (swelling of face)
  2. Device failure
  3. Periodontitis (inflammation of the tissue around the teeth)
  4. Prostatic specific antigen increased
  5. Abdominal discomfort
  6. Anaemia (lack of blood)
  7. Anaphylactic reaction (serious allergic reaction)
  8. Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)
  9. Atypical femur fracture
  10. Back pain

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 14 people, 15.38%
  2. High Blood Cholesterol: 11 people, 12.09%
  3. Stress And Anxiety: 9 people, 9.89%
  4. Depression: 7 people, 7.69%
  5. Prostate Cancer: 6 people, 6.59%
  6. Bipolar Disorder (mood disorder): 6 people, 6.59%
  7. Arthritis (form of joint disorder that involves inflammation of one or more joints): 6 people, 6.59%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Accupril and Actonel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Accupril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Actonel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Accupril and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Actonel and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on quinapril hydrochloride and risedronate sodium (the active ingredients of Accupril and Actonel, respectively), and Accupril and Actonel (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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