Accuretic and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Accuretic (hydrochlorothiazide; quinapril hydrochloride) and Actos (pioglitazone hydrochloride). Common drug interactions include blood cholesterol increased among females and haematoma among males.

The phase IV clinical study analyzes what interactions people have when they take Accuretic and Actos. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Accuretic?

Accuretic has active ingredients of hydrochlorothiazide; quinapril hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 1,106 Accuretic users. Check the latest studies of Accuretic.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 17, 2026

30 people who take Accuretic and Actos together, and have interactions are studied.

What are the common drug interactions of Accuretic and Actos, by gender? *:

female:

Blood cholesterol increased
Blood glucose increased
Drug hypersensitivity
Asthenia (weakness)
Chest discomfort
Chest pain
Cystitis (inflammation of the wall of the bladder)
Dehydration (dryness resulting from the removal of water)
Drug ineffective
Essential hypertension (primary hypertension)

male:

Haematoma (collection of blood outside the blood vessels)
Blood glucose decreased
Benign prostatic hyperplasia (benign enlargement of the prostate)
Blood cholesterol increased
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Discomfort
Essential hypertension (primary hypertension)

What are the common drug interactions of Accuretic and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Haematoma (collection of blood outside the blood vessels)
Drug hypersensitivity
Headache (pain in head)
Acute myocardial infarction (acute heart attack)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Back pain
Benign prostatic hyperplasia (benign enlargement of the prostate)
Blood cholesterol increased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

50-59:

Blood glucose decreased
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Joint dislocation (a joint position is changed from normal position)
Muscular weakness (muscle weakness)
Abdominal pain
Arthralgia (joint pain)
Asthma
Back pain
Blood cholesterol increased
Cervical spinal stenosis (narrowing of the spinal canal in the neck)

60+:

Blood glucose increased
Asthenia (weakness)
Blood cholesterol increased
Blood glucose decreased
Candidiasis (candidiasis or thrush is a fungal infection)
Cardiac failure congestive
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Colorectal cancer (colon cancer or bowel cancer)
Diarrhoea
Discomfort

What are the existing conditions these people have? *

Type 2 Diabetes: 9 people, 30.00%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 4 people, 13.33%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 13.33%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 6.67%
Anaemia (lack of blood): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Accuretic and Actos?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously