Acetazolamide and Combivent drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acetazolamide (acetazolamide) and Combivent (albuterol sulfate; ipratropium bromide). Common drug interactions include gangrene among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Acetazolamide and Combivent. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Acetazolamide?

Acetazolamide has active ingredients of acetazolamide. It is often used in pseudotumor cerebri. eHealthMe is studying from 6,178 Acetazolamide users. Check the latest studies of Acetazolamide.

What is Combivent?

Combivent has active ingredients of albuterol sulfate; ipratropium bromide. It is often used in asthma. eHealthMe is studying from 35,341 Combivent users. Check the latest studies of Combivent.



On Jul, 08, 2026

39 people who take Acetazolamide and Combivent together, and have interactions are studied.

Acetazolamide and Combivent drug interactions.

What are the common drug interactions of Acetazolamide and Combivent, by gender? *:

female:

  1. Gangrene (body tissue dies)
  2. Haemodynamic instability (disturbances in the blood movement in our body)
  3. Heparin-induced thrombocytopenia
  4. Hypotension (abnormally low blood pressure)
  5. Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
  6. Multi-organ failure (multisystem organ failure)
  7. Oral discomfort (pain or irritation in mouth)
  8. Renal failure (kidney dysfunction)
  9. Serratia sepsis (a bacterial whole body inflammation)
  10. Skin discolouration (change of skin colour)

male:

  1. Cardiac failure congestive
  2. Renal failure acute (rapid kidney dysfunction)
  3. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  4. Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
  5. Hepatic failure (liver failure)
  6. Liver disorder (liver diseases)
  7. Pulmonary hypertension (increase in blood pressure in the lung artery)
  8. Septic shock (shock due to blood infection)
  9. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  10. Pneumonia

What are the common drug interactions of Acetazolamide and Combivent, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Abdominal infection
  2. Abdominal pain upper
  3. Acidosis (build-up of carbon dioxide in the blood)
  4. Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
  5. Asthenia (weakness)
  6. Back pain
  7. Blood cholesterol increased
  8. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  9. Bronchopleural fistula
  10. Cardiac failure congestive

30-39:

  1. Acute respiratory failure
  2. Anaemia (lack of blood)
  3. Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
  4. Burning sensation
  5. Chronic respiratory failure
  6. Colonic polyp (extra part of colon tissue grow in intestine)
  7. Constipation
  8. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  9. Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
  10. Dizziness

40-49:

n/a

50-59:

  1. Encephalopathy (functioning of the brain is affected by some agent or condition)
  2. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  3. Hepatic failure (liver failure)
  4. Liver disorder (liver diseases)
  5. Pulmonary hypertension (increase in blood pressure in the lung artery)
  6. Septic shock (shock due to blood infection)
  7. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  8. Pneumonia
  9. Serratia bacteraemia (bacterial blood infection)
  10. Staphylococcal bacteraemia (a bacterial infection of blood)

60+:

  1. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  2. Dyspnoea (difficult or laboured respiration)
  3. Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
  4. Disseminated intravascular coagulation (systemic activation of blood coagulation)
  5. Gangrene (body tissue dies)
  6. Haemodynamic instability (disturbances in the blood movement in our body)
  7. Heparin-induced thrombocytopenia
  8. Hypotension (abnormally low blood pressure)
  9. Multi-organ failure (multisystem organ failure)
  10. Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

  1. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 6 people, 15.38%
  2. Serratia Sepsis (a bacterial whole body inflammation): 3 people, 7.69%
  3. Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 5.13%
  4. Cystic Fibrosis (disease of the secretary glands): 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Acetazolamide and Combivent:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Acetazolamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Combivent:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Acetazolamide and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Combivent and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on acetazolamide and albuterol sulfate; ipratropium bromide (the active ingredients of Acetazolamide and Combivent, respectively), and Acetazolamide and Combivent (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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