Acetazolamide and Isosorbide dinitrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acetazolamide (acetazolamide) and Isosorbide dinitrate (isosorbide dinitrate). Common drug interactions include exercise tolerance decreased among females and toxic epidermal necrolysis among males.

The phase IV clinical study analyzes what interactions people have when they take Acetazolamide and Isosorbide dinitrate. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Acetazolamide?

Acetazolamide has active ingredients of acetazolamide. It is often used in pseudotumor cerebri. eHealthMe is studying from 6,178 Acetazolamide users. Check the latest studies of Acetazolamide.

What is Isosorbide dinitrate?

Isosorbide dinitrate has active ingredients of isosorbide dinitrate. It is often used in angina. eHealthMe is studying from 13,180 Isosorbide dinitrate users. Check the latest studies of Isosorbide dinitrate.

On Jul, 05, 2026

34 people who take Acetazolamide and Isosorbide dinitrate together, and have interactions are studied.

Acetazolamide and Isosorbide dinitrate drug interactions.

What are the common drug interactions of Acetazolamide and Isosorbide Dinitrate, by gender? *:

female:

Exercise tolerance decreased
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypokalaemia (low potassium)
Ill-defined disorder
Impaired gastric emptying
Incision site pain
Infusion related reaction

male:

Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Anuria (failure of the kidneys to produce urine)
Hypotension (abnormally low blood pressure)
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Hypovolaemia (a decreased volume of circulating blood in the body)
Loss of consciousness
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Polyuria (production of too much dilute urine)
Renal failure (kidney dysfunction)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)

What are the common drug interactions of Acetazolamide and Isosorbide Dinitrate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Electrocardiogram qrs complex prolonged
Hyperkalaemia (damage to or disease of the kidney)
Hypotension (abnormally low blood pressure)
Hypovolaemia (a decreased volume of circulating blood in the body)
Loss of consciousness
Polyuria (production of too much dilute urine)
Renal failure (kidney dysfunction)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Torsade de pointes (a abnormal heart rate with abnormal beating pattern)
Ventricular fibrillation (abnormally irregular heart rhythm)

50-59:

n/a

60+:

Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Dizziness
Hypoaesthesia (reduced sense of touch or sensation)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Oedema (fluid collection in tissue)
Rhinorrhoea (watery mucus discharge from the nose)
Vomiting
Wheezing (a high-pitched whistling sound made while you breath)
Abdominal pain

What are the existing conditions these people have? *

Fever: 22 people, 64.71%
Stress And Anxiety: 22 people, 64.71%
Ards (Acute Respiratory Distress Syndrome) (sudden failure of the respiratory (breathing) system): 22 people, 64.71%
Sedation: 22 people, 64.71%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 22 people, 64.71%
Pneumonia: 22 people, 64.71%
Constipation: 22 people, 64.71%
Depression: 22 people, 64.71%
High Blood Pressure: 22 people, 64.71%
Diarrhea: 22 people, 64.71%

* Approximation only. Some reports may have incomplete information.

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