Acetazolamide and Pregabalin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acetazolamide (acetazolamide) and Pregabalin (pregabalin). Common drug interactions include arthralgia among females and hypoxia among males.

The phase IV clinical study analyzes what interactions people have when they take Acetazolamide and Pregabalin. It is created by eHealthMe based on reports of 96 people who take the same drugs from the FDA, and is updated regularly.

What is Acetazolamide?

Acetazolamide has active ingredients of acetazolamide. It is often used in pseudotumor cerebri. eHealthMe is studying from 6,178 Acetazolamide users. Check the latest studies of Acetazolamide.

What is Pregabalin?

Pregabalin has active ingredients of pregabalin. It is often used in fibromyalgia. eHealthMe is studying from 74,070 Pregabalin users. Check the latest studies of Pregabalin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 17, 2026

96 people who take Acetazolamide and Pregabalin together, and have interactions are studied.

Acetazolamide and Pregabalin drug interactions.

What are the common drug interactions of Acetazolamide and Pregabalin, by gender? *:

female:

Arthralgia (joint pain)
Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Chills (felling of cold)
Constipation
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Diarrhoea
Drug hypersensitivity
Dysphagia (a condition in which swallowing is difficult or painful)

male:

Hypoxia (low oxygen in tissues)
Organising pneumonia (pathologically by the presence in the distal air spaces of buds of granulation tissue)
Allodynia (a condition in which pain is caused by a stimulus that does not normally elicit pain)
Cardiomegaly (increased size of heart than normal)
Cardiorenal syndrome (kidney failure and heart failure)
Communication disorder (speech and language disorder)
Confusional state
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Epistaxis (bleed from the nose)
Feeling of despair

What are the common drug interactions of Acetazolamide and Pregabalin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Allodynia (a condition in which pain is caused by a stimulus that does not normally elicit pain)
Hyperaesthesia

20-29:

Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Drug ineffective
Headache (pain in head)
Palpitations (feelings or sensations that your heart is pounding or racing)
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Abdominal infection
Abdominal pain upper
Acidosis (build-up of carbon dioxide in the blood)
Anxiety

30-39:

Anger
Communication disorder (speech and language disorder)
Feeling of despair
Irritability
Personality change
Social avoidant behaviour (avoiding social connection a personality disorder)
Contusion (a type of hematoma of tissue in which capillaries)
Activated partial thromboplastin time prolonged
Anti factor x antibody positive
Coagulopathy (blood's ability to clot is impaired)

40-49:

Headache (pain in head)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Blindness
Blindness unilateral
Blood glucose increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Eye disorder
Fall
Fungal infection
Hypersensitivity

50-59:

Haematemesis (vomiting of blood)
Hypotension (abnormally low blood pressure)
Melaena (the passage of black, tarry stools)
Neuropathy peripheral (surface nerve damage)
Peripheral vascular disorder
Pleural effusion (water on the lungs)
Pulmonary oedema (fluid accumulation in the lungs)
Pyrexia (fever)
Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)

60+:

Hypoxia (low oxygen in tissues)
Organising pneumonia (pathologically by the presence in the distal air spaces of buds of granulation tissue)
Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)
Asthenia (weakness)
Back pain
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Chills (felling of cold)
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Diarrhoea

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 8 people, 8.33%
Pain: 7 people, 7.29%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 7.29%
Hereditary Angioedema (recurrent episodes of severe swelling): 7 people, 7.29%
Neuropathy Peripheral (surface nerve damage): 6 people, 6.25%
Neuralgia (pain in one or more nerves): 6 people, 6.25%
Multiple Myeloma (cancer of the plasma cells): 6 people, 6.25%
Respiratory Disorder (respiratory disease): 5 people, 5.21%
Nausea (feeling of having an urge to vomit): 5 people, 5.21%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 5.21%

* Approximation only. Some reports may have incomplete information.

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