Acetazolamide and Solu-cortef drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acetazolamide (acetazolamide) and Solu-cortef (hydrocortisone sodium succinate). Common drug interactions include ear infection among females and burkholderia test positive among males.

The phase IV clinical study analyzes what interactions people have when they take Acetazolamide and Solu-cortef. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Acetazolamide?

Acetazolamide has active ingredients of acetazolamide. It is often used in pseudotumor cerebri. eHealthMe is studying from 6,178 Acetazolamide users. Check the latest studies of Acetazolamide.

What is Solu-cortef?

Solu-cortef has active ingredients of hydrocortisone sodium succinate. eHealthMe is studying from 7,983 Solu-cortef users. Check the latest studies of Solu-cortef.



On Jul, 10, 2026

21 people who take Acetazolamide and Solu-cortef together, and have interactions are studied.

Acetazolamide and Solu-cortef drug interactions.

What are the common drug interactions of Acetazolamide and Solu-Cortef, by gender? *:

female:

  1. Ear infection
  2. Sinusitis (inflammation of sinus)
  3. Migraine (headache)
  4. Nephrolithiasis (calculi in the kidneys)
  5. Urinary tract infection
  6. Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
  7. Breast cancer
  8. Dry eye (lack of adequate tears)
  9. Gastric dysplasia (stomach with abnormality of development)
  10. Gastritis (inflammation of stomach)

male:

  1. Burkholderia test positive
  2. Hepatic enzyme increased
  3. Syncope (loss of consciousness with an inability to maintain postural tone)
  4. Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
  5. Ventricular dysfunction (heart dysfunction)
  6. Ventricular failure (heart failure)
  7. Asthenia (weakness)
  8. Dizziness
  9. Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
  10. Cardiac failure

What are the common drug interactions of Acetazolamide and Solu-Cortef, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Agitation (state of anxiety or nervous excitement)
  2. Cardiac arrest
  3. Collapse (sudden functional breakdown)
  4. Confusion
  5. Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
  6. Disorientation (disability in which the senses of time, direction, and recognition of people and places)
  7. Headache (pain in head)
  8. Hyperpyrexia malignant (disease passed down through families that causes a fast rise in body temperature (fever) and severe muscle contractions- infectious)
  9. Hypotension (abnormally low blood pressure)
  10. Hypoxia (low oxygen in tissues)

30-39:

n/a

40-49:

  1. Death
  2. Eosinophilia (eosinophil count in the peripheral blood exceeds)
  3. Nervous system disorder (a general class of medical conditions affecting the nervous system)
  4. Sinusitis (inflammation of sinus)
  5. Toxic skin eruption (skin breakdown due to toxic substance)
  6. Upper respiratory tract infection
  7. Hepatic enzyme increased
  8. Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
  9. Blood alkaline phosphatase increased
  10. Ear infection

50-59:

n/a

60+:

  1. Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
  2. Cystitis haemorrhagic (blood in the urine and painful voiding)
  3. Hypoxia (low oxygen in tissues)
  4. Organising pneumonia (pathologically by the presence in the distal air spaces of buds of granulation tissue)
  5. Pneumonia influenzal (the flu with pneumonia)

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 6 people, 28.57%
  2. Primary Immunodeficiency Syndrome: 5 people, 23.81%
  3. Pharyngitis (inflammation of the pharynx, causing a sore throat): 3 people, 14.29%
  4. Hereditary Angioedema (recurrent episodes of severe swelling): 3 people, 14.29%
  5. Fabry's Disease (build up of a particular type of fat, called globotriaosylceramide, in the body's cells): 3 people, 14.29%
  6. Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Acetazolamide and Solu-cortef:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Acetazolamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Solu-cortef:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Acetazolamide and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Solu-cortef and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on acetazolamide and hydrocortisone sodium succinate (the active ingredients of Acetazolamide and Solu-cortef, respectively), and Acetazolamide and Solu-cortef (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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