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Aciphex and Benlysta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aciphex (rabeprazole sodium) and Benlysta (belimumab). Common drug interactions include pruritus among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Aciphex and Benlysta. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Aciphex?

Aciphex has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 25,301 Aciphex users. Check the latest studies of Aciphex.

What is Benlysta?

Benlysta has active ingredients of belimumab. It is often used in systemic lupus erythematosus. eHealthMe is studying from 23,528 Benlysta users. Check the latest studies of Benlysta.

On Jul, 08, 2026

27 people who take Aciphex and Benlysta together, and have interactions are studied.

Aciphex and Benlysta drug interactions.

What are the common drug interactions of Aciphex and Benlysta, by gender? *:

female:

  1. Pruritus (severe itching of the skin)
  2. Dyspnoea (difficult or laboured respiration)
  3. Hypersensitivity
  4. Pain
  5. Vomiting
  6. Alopecia (absence of hair from areas of the body)
  7. Anaphylactic reaction (serious allergic reaction)
  8. Blood pressure increased
  9. Accidental exposure
  10. Arthralgia (joint pain)

male:

  1. Pain
  2. White blood cell count decreased

What are the common drug interactions of Aciphex and Benlysta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Fatigue (feeling of tiredness)
  2. Pyrexia (fever)
  3. Diarrhoea
  4. Hypersensitivity
  5. Malaise (a feeling of general discomfort or uneasiness)
  6. Accidental exposure
  7. Chest discomfort
  8. Chills (felling of cold)
  9. Decreased appetite
  10. Dehydration (dryness resulting from the removal of water)

50-59:

  1. Nausea (feeling of having an urge to vomit)
  2. Diarrhoea
  3. Anaphylactic reaction (serious allergic reaction)
  4. Blood pressure increased
  5. Throat irritation
  6. Urticaria (rash of round, red welts on the skin that itch intensely)
  7. Diplopia (double vision)
  8. Dizziness
  9. Headache (pain in head)
  10. Pruritus (severe itching of the skin)

60+:

  1. Nausea (feeling of having an urge to vomit)
  2. Pain
  3. Ulcer
  4. Vomiting
  5. White blood cell count decreased
  6. Cellulitis (infection under the skin)
  7. Diarrhoea
  8. Dry mouth
  9. Flatulence (flatus expelled through the anus)
  10. Headache (pain in head)

What are the existing conditions these people have? *

  1. Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Aciphex and Benlysta?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Aciphex and Benlysta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Aciphex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Benlysta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Aciphex and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Benlysta and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on rabeprazole sodium and belimumab (the active ingredients of Aciphex and Benlysta, respectively), and Aciphex and Benlysta (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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