Aciphex and Femara drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aciphex (rabeprazole sodium) and Femara (letrozole). Common drug interactions include nausea among females.

The phase IV clinical study analyzes what interactions people have when they take Aciphex and Femara. It is created by eHealthMe based on reports of 80 people who take the same drugs from the FDA, and is updated regularly.

What is Aciphex?

Aciphex has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 25,301 Aciphex users. Check the latest studies of Aciphex.

What is Femara?

Femara has active ingredients of letrozole. It is often used in breast cancer. eHealthMe is studying from 19,630 Femara users. Check the latest studies of Femara.

On Aug, 02, 2026

80 people who take Aciphex and Femara together, and have interactions are studied.

What are the common drug interactions of Aciphex and Femara, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Anxiety
Bone disorder
Cellulitis (infection under the skin)
Fall
Arthralgia (joint pain)
Chest pain
Mouth ulceration (mouth ulcers)
Osteonecrosis of jaw (death of bone of jaw)
Pain in jaw

male:

n/a

What are the common drug interactions of Aciphex and Femara, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain upper
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Adjustment disorder
Alopecia (absence of hair from areas of the body)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Arthralgia (joint pain)
Asthma
Axillary pain
Back pain

40-49:

Abdominal pain upper
Anxiety
Back pain
Blood cholesterol increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest pain
Chills (felling of cold)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Constipation
Depression

50-59:

Nausea (feeling of having an urge to vomit)
Pain
Vomiting
Cellulitis (infection under the skin)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Mouth ulceration (mouth ulcers)
Pain in jaw
Weight decreased
Arthralgia (joint pain)
Back pain

60+:

Renal failure (kidney dysfunction)
Diarrhoea
Anxiety
Aortic disorder
Aortic valve incompetence
Aphasia (damage to the parts of the brain that control language)
Arrhythmia (irregular heartbeat)
Arthralgia (joint pain)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Atrial thrombosis (blood clot that develops in an artery)

What are the existing conditions these people have? *

Breast Cancer Metastatic: 33 people, 41.25%
Irritable Bowel Syndrome: 22 people, 27.50%
Osteoporosis (bones weak and more likely to break): 12 people, 15.00%
Multiple Myeloma (cancer of the plasma cells): 11 people, 13.75%
Insomnia (sleeplessness): 9 people, 11.25%
Osteopenia (a condition where bone mineral density is lower than normal): 8 people, 10.00%
Hypersensitivity: 8 people, 10.00%
Pain: 7 people, 8.75%
Headache (pain in head): 7 people, 8.75%
Metastases To Bone (cancer spreads to bone): 4 people, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Aciphex and Femara?

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