Aciphex and Generlac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aciphex (rabeprazole sodium) and Generlac (lactulose). Common drug interactions include migraine among females and hepatic infection among males.

The phase IV clinical study analyzes what interactions people have when they take Aciphex and Generlac. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Aciphex?

Aciphex has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 25,301 Aciphex users. Check the latest studies of Aciphex.

What is Generlac?

Generlac has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 657 Generlac users. Check the latest studies of Generlac.



On Jul, 15, 2026

13 people who take Aciphex and Generlac together, and have interactions are studied.

Aciphex and Generlac drug interactions.

What are the common drug interactions of Aciphex and Generlac, by gender? *:

female:

  1. Migraine (headache)
  2. Osteopenia (a condition where bone mineral density is lower than normal)
  3. Flushing (the warm, red condition of human skin)
  4. Pulmonary embolism (blockage of the main artery of the lung)
  5. Vitamin b12 increased
  6. Intervertebral disc degeneration (spinal disc degeneration)
  7. Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
  8. Scoliosis (a medical condition in which a person's spine is curved from side to side)
  9. Abdominal pain upper
  10. Contusion (a type of hematoma of tissue in which capillaries)

male:

  1. Hepatic infection
  2. Liver transplant rejection (failure of liver transplant)
  3. Neutropenia (an abnormally low number of neutrophils)

What are the common drug interactions of Aciphex and Generlac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Hepatic infection
  2. Liver transplant rejection (failure of liver transplant)
  3. Neutropenia (an abnormally low number of neutrophils)

40-49:

  1. Abdominal pain upper
  2. Contusion (a type of hematoma of tissue in which capillaries)
  3. Diarrhoea
  4. Dyspepsia (indigestion)
  5. Gastrointestinal pain
  6. Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
  7. Nausea (feeling of having an urge to vomit)
  8. Rhinorrhoea (watery mucus discharge from the nose)

50-59:

  1. Affect lability (emotional incontinence)
  2. Anaemia (lack of blood)
  3. Vitamin b12 increased
  4. Intervertebral disc degeneration (spinal disc degeneration)
  5. Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
  6. Pulmonary embolism (blockage of the main artery of the lung)
  7. Cervical cord compression (compression of spinal cord at site of cervical vertebrae)
  8. Scoliosis (a medical condition in which a person's spine is curved from side to side)
  9. Anxiety
  10. Central nervous system lesion (an abnormality in tissue of brain or spinal cord)

60+:

n/a

What are the existing conditions these people have? *

  1. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 10 people, 76.92%
  2. Stress And Anxiety: 7 people, 53.85%
  3. Nausea (feeling of having an urge to vomit): 6 people, 46.15%
  4. Muscle Spasms (muscle contraction): 6 people, 46.15%
  5. Gait Disturbance: 4 people, 30.77%
  6. High Blood Pressure: 3 people, 23.08%
  7. Nausea And Vomiting: 2 people, 15.38%
  8. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 7.69%
  9. Anaemia (lack of blood): 1 person, 7.69%
  10. Back Pain: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Aciphex and Generlac?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Aciphex and Generlac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Aciphex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Generlac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Aciphex and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Generlac and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on rabeprazole sodium and lactulose (the active ingredients of Aciphex and Generlac, respectively), and Aciphex and Generlac (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



Recent studies on eHealthMe: