Aciphex and Renagel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aciphex (rabeprazole sodium) and Renagel (sevelamer hydrochloride). Common drug interactions include pain in extremity among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Aciphex and Renagel. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Aciphex?

Aciphex has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 25,301 Aciphex users. Check the latest studies of Aciphex.

What is Renagel?

Renagel has active ingredients of sevelamer hydrochloride. eHealthMe is studying from 8,246 Renagel users. Check the latest studies of Renagel.

On Jul, 06, 2026

39 people who take Aciphex and Renagel together, and have interactions are studied.

What are the common drug interactions of Aciphex and Renagel, by gender? *:

female:

Pain in extremity
Rash papular (redness with papule)
Renal failure (kidney dysfunction)
Skin hyperpigmentation (disorders affect the colour of your skin)
Skin hypertrophy (skin cells enlarges)
Skin induration (an abnormally hard spot or area on the skin)
Skin plaque (red, scaly patches to appear on the skin)
Skin tightness
Nausea (feeling of having an urge to vomit)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

male:

Death
Renal failure (kidney dysfunction)
Family stress
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypoaesthesia (reduced sense of touch or sensation)
Malaise (a feeling of general discomfort or uneasiness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Rash erythematous (redness of the skin)
Rash papular (redness with papule)

What are the common drug interactions of Aciphex and Renagel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Back pain
Emotional distress
Exfoliative rash (scaly red generalized skin rash)
Gait disturbance
Hyperkeratosis (thickening of the outer layer of the skin)
Joint range of motion decreased (disease of joint movement)
Muscle fatigue (a condition in which muscles cannot exert their normal force)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

40-49:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)

50-59:

Arthropathy
Chronic kidney disease
Deformity (disfigurement)
Dry skin
Gait disturbance
Hypoaesthesia (reduced sense of touch or sensation)
Induration (thickening of tissue)
Joint stiffness
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Mitral valve disease (disease of mitral valve of heart)

60+:

Nausea (feeling of having an urge to vomit)
Renal failure (kidney dysfunction)
Chronic kidney disease
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hyperlipidaemia (presence of excess lipids in the blood)
Malaise (a feeling of general discomfort or uneasiness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Blood pressure systolic increased
Circulatory collapse

What are the existing conditions these people have? *

High Blood Pressure: 16 people, 41.03%
Pain: 10 people, 25.64%
Anaemia (lack of blood): 7 people, 17.95%
High Blood Cholesterol: 6 people, 15.38%
Renal Disorder (kidney disease): 5 people, 12.82%
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood): 5 people, 12.82%
Type 2 Diabetes: 4 people, 10.26%
Bloody Peritoneal Effluent: 4 people, 10.26%
Diabetes: 4 people, 10.26%
Diarrhea: 4 people, 10.26%

* Approximation only. Some reports may have incomplete information.

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