Aciphex and Roxicet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aciphex (rabeprazole sodium) and Roxicet (acetaminophen; oxycodone hydrochloride). Common drug interactions include joint stiffness among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Aciphex and Roxicet. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Aciphex?

Aciphex has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 25,301 Aciphex users. Check the latest studies of Aciphex.

What is Roxicet?

Roxicet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 2,254 Roxicet users. Check the latest studies of Roxicet.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

46 people who take Aciphex and Roxicet together, and have interactions are studied.

What are the common drug interactions of Aciphex and Roxicet, by gender? *:

female:

Joint stiffness
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Osteonecrosis of jaw (death of bone of jaw)
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Atrioventricular block (heart block)
Bunion (a painful swelling on the first joint of the big toe)
Carpal tunnel decompression
Dyspnoea exertional (breathlessness or shortness of breath)
Fatigue (feeling of tiredness)
Intervertebral disc protrusion (spinal disc protrusion)

male:

Abdominal pain
Cardiac failure congestive
Mouth haemorrhage (bleeding from mouth)
Nephrogenic anaemia (anaemia due to kidney disease)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Pruritus (severe itching of the skin)
Rectal haemorrhage (bleeding from anus)
Renal injury (kidney injury)
Sensation of foreign body

What are the common drug interactions of Aciphex and Roxicet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Arthralgia (joint pain)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Pulmonary embolism (blockage of the main artery of the lung)
Anxiety
Depression
Emotional disorder
Headache (pain in head)
Hypertension (high blood pressure)

30-39:

n/a

40-49:

Adrenal haemorrhage (bleeding into the adrenal gland)
Anaemia (lack of blood)
Angiotensin converting enzyme increased
Ankle fracture
Blood potassium decreased
Chest discomfort
Cluster headache (one-sided head pain with tearing)
Diastolic dysfunction
Dry eye (lack of adequate tears)
Dry mouth

50-59:

Ventricular fibrillation (abnormally irregular heart rhythm)
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Depression
Drug ineffective
Intervertebral disc protrusion (spinal disc protrusion)
Stress
Cardiac failure congestive
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Mouth haemorrhage (bleeding from mouth)

60+:

Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Synovial cyst (cyst of joint filled with synovial fluid)
Bruxism (habitual grinding of the teeth, typically during sleep)
Confusional state
Hypoaesthesia (reduced sense of touch or sensation)
Injury
Mouth ulceration (mouth ulcers)
Oral infection
Vertebral foraminal stenosis (narrowing of the intervertebral foramen)
Abscess jaw (tooth abscess or root abscess)

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 12 people, 26.09%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 19.57%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 19.57%
High Blood Pressure: 4 people, 8.70%
Stress And Anxiety: 3 people, 6.52%
Osteoporosis (bones weak and more likely to break): 3 people, 6.52%
High Blood Cholesterol: 3 people, 6.52%
Drowsiness: 3 people, 6.52%

* Approximation only. Some reports may have incomplete information.

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