Aciphex and Se drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aciphex (rabeprazole sodium) and Se (selenium). Common drug interactions include urethral stenosis among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Aciphex and Se. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Aciphex?

Aciphex has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 25,301 Aciphex users. Check the latest studies of Aciphex.

What is Se?

Se has active ingredients of selenium. eHealthMe is studying from 5,604 Se users. Check the latest studies of Se.



On Jul, 16, 2026

19 people who take Aciphex and Se together, and have interactions are studied.

Aciphex and Se drug interactions.

What are the common drug interactions of Aciphex and Se, by gender? *:

female:

  1. Urethral stenosis (narrowing of the urethra, may cause decreased urine output)
  2. Urinary tract infection
  3. Urticaria (rash of round, red welts on the skin that itch intensely)
  4. Vertigo positional
  5. Weight increased
  6. Wheezing (a high-pitched whistling sound made while you breath)
  7. Abdominal distension
  8. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  9. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  10. Infusion site erythema (reddening of the skin at infusion site)

male:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Ankle fracture
  3. Osteopenia (a condition where bone mineral density is lower than normal)
  4. Osteoporosis (bones weak and more likely to break)
  5. Pain
  6. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  7. Syncope (loss of consciousness with an inability to maintain postural tone)
  8. Teeth brittle (other half has a defect in the teeth)
  9. Tooth fracture
  10. Tooth loss

What are the common drug interactions of Aciphex and Se, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Tooth fracture
  2. Tooth loss
  3. Gallbladder disorder
  4. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  5. Ankle fracture
  6. Anxiety
  7. Bone density decreased
  8. Bone loss
  9. Chronic kidney disease
  10. Emotional distress

40-49:

n/a

50-59:

  1. Blood alkaline phosphatase increased
  2. Breast mass
  3. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  4. Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
  5. Bunion (a painful swelling on the first joint of the big toe)
  6. Cellulitis (infection under the skin)
  7. Cerumen impaction
  8. Cervical radiculopathy (disturbance of nerve function that causes pain in the upper body)
  9. Chest pain
  10. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

60+:

  1. Chronic kidney disease
  2. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  3. Syncope (loss of consciousness with an inability to maintain postural tone)
  4. Staphylococcal infection (an infection with staphylococcus bacteria)

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 6 people, 31.58%
  2. Pain: 3 people, 15.79%
  3. Cough: 2 people, 10.53%
  4. Multiple Myeloma (cancer of the plasma cells): 2 people, 10.53%
  5. Hepatitis B: 2 people, 10.53%
  6. Dyspnea (difficult or laboured breathing): 2 people, 10.53%
  7. Diarrhea: 2 people, 10.53%
  8. Herpes Zoster: 2 people, 10.53%
  9. Hiv Infection: 2 people, 10.53%
  10. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

Do you take Aciphex and Se?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Aciphex and Se:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Aciphex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Se:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Aciphex and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Se and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on rabeprazole sodium and selenium (the active ingredients of Aciphex and Se, respectively), and Aciphex and Se (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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