Aciphex and Tegretol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aciphex (rabeprazole sodium) and Tegretol (carbamazepine). Common drug interactions include diabetic neuropathy among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Aciphex and Tegretol. It is created by eHealthMe based on reports of 79 people who take the same drugs from the FDA, and is updated regularly.

What is Aciphex?

Aciphex has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 25,301 Aciphex users. Check the latest studies of Aciphex.

What is Tegretol?

Tegretol has active ingredients of carbamazepine. It is often used in epilepsy. eHealthMe is studying from 45,969 Tegretol users. Check the latest studies of Tegretol.

On Aug, 10, 2026

79 people who take Aciphex and Tegretol together, and have interactions are studied.

What are the common drug interactions of Aciphex and Tegretol, by gender? *:

female:

Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Pancreatitis chronic (chronic inflammation of pancreas)
Cough
Depression
Gastritis (inflammation of stomach)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Drug dependence
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)

male:

Renal failure (kidney dysfunction)
Chronic kidney disease
Drug level increased
Oedema (fluid collection in tissue)
Weight increased
Cardiomegaly (increased size of heart than normal)
Dental caries
Peripheral swelling
Nephropathy (damage to or disease of a kidney)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

What are the common drug interactions of Aciphex and Tegretol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Cold sweat

10-19:

n/a

20-29:

n/a

30-39:

Arthralgia (joint pain)
Back pain
Weight decreased
Body mass index increased
Drug level decreased
Drug level increased
Hypertension (high blood pressure)
Oedema (fluid collection in tissue)
Weight increased
Cardiomegaly (increased size of heart than normal)

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Renal injury (kidney injury)
Pain
Asthenia (weakness)
Chest pain
Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Drug ineffective

50-59:

Fatigue (feeling of tiredness)
Gallbladder disorder
Insomnia (sleeplessness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Thrombosis (formation of a blood clot inside a blood vessel)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Allergic colitis (inflammation of the colon due to allergy)
Aneurysm (enlargement of an artery caused by a weakening of the artery wall)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Antithrombin iii increased

60+:

Pain
Balance disorder
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Bile duct stenosis (abnormal narrowing of the common bile duct)
Blood calcium increased
Bone disorder
Brain neoplasm (tumour of brain)

What are the existing conditions these people have? *

Pain: 19 people, 24.05%
Depression: 10 people, 12.66%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 8.86%
Insomnia (sleeplessness): 7 people, 8.86%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 8.86%
High Blood Cholesterol: 6 people, 7.59%
High Blood Pressure: 6 people, 7.59%
Stress And Anxiety: 6 people, 7.59%
Nausea (feeling of having an urge to vomit): 6 people, 7.59%
Intervertebral Disc Degeneration (spinal disc degeneration): 5 people, 6.33%

* Approximation only. Some reports may have incomplete information.

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