Aciphex and Ursodiol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aciphex (rabeprazole sodium) and Ursodiol (ursodiol). Common drug interactions include renal haemorrhage among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Aciphex and Ursodiol. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Aciphex?

Aciphex has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 25,301 Aciphex users. Check the latest studies of Aciphex.

What is Ursodiol?

Ursodiol has active ingredients of ursodiol. It is often used in primary biliary cirrhosis. eHealthMe is studying from 19,061 Ursodiol users. Check the latest studies of Ursodiol.

On Aug, 07, 2026

53 people who take Aciphex and Ursodiol together, and have interactions are studied.

What are the common drug interactions of Aciphex and Ursodiol, by gender? *:

female:

Renal haemorrhage (bleeding from kidney)
Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Scar
Scleroderma (hard skin)
Skin lesion
Visual acuity reduced (reduced clearness of vision)
Vitamin d deficiency
Vomiting
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Clostridial infection (infectious conditions by clostridium bacteria)
Escherichia bacteraemia (presence of bacteria escherichia coli in the blood)
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Diarrhoea
Vomiting
Cheilitis (infection of lips)
Gout (uric acid crystals building up in the body)

What are the common drug interactions of Aciphex and Ursodiol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Vomiting

10-19:

n/a

20-29:

Infection
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Nephrolithiasis (calculi in the kidneys)
Abdominal pain upper
Cystic fibrosis (disease of the secretary glands)
Pulmonary thrombosis (scarring in the lungs)

30-39:

Hepatic infection
Liver transplant rejection (failure of liver transplant)
Neutropenia (an abnormally low number of neutrophils)

40-49:

Diarrhoea
Drug ineffective

50-59:

Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Decreased appetite
Disturbance in attention
Dysgeusia (disorder of the sense of taste)
Dysuria (painful or difficult urination)
Hair disorder
Hypoaesthesia (reduced sense of touch or sensation)
Irritability
Lethargy (tiredness)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Clostridial infection (infectious conditions by clostridium bacteria)
Diarrhoea
Escherichia bacteraemia (presence of bacteria escherichia coli in the blood)
Vomiting
Cheilitis (infection of lips)
Gout (uric acid crystals building up in the body)

What are the existing conditions these people have? *

Pain: 13 people, 24.53%
High Blood Cholesterol: 12 people, 22.64%
Cystic Fibrosis (disease of the secretary glands): 10 people, 18.87%
Gout (uric acid crystals building up in the body): 9 people, 16.98%
Hypersensitivity: 7 people, 13.21%
High Blood Pressure: 6 people, 11.32%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 6 people, 11.32%
Back Pain: 5 people, 9.43%
Cardiac Disorder: 5 people, 9.43%
Sleep Disorder: 5 people, 9.43%

* Approximation only. Some reports may have incomplete information.

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