Aciphex and Zestoretic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aciphex (rabeprazole sodium) and Zestoretic (hydrochlorothiazide; lisinopril). Common drug interactions include carotid artery stenosis among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Aciphex and Zestoretic. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Aciphex?

Aciphex has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 25,301 Aciphex users. Check the latest studies of Aciphex.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

On Aug, 01, 2026

35 people who take Aciphex and Zestoretic together, and have interactions are studied.

Aciphex and Zestoretic drug interactions.

What are the common drug interactions of Aciphex and Zestoretic, by gender? *:

female:

Carotid artery stenosis (narrowing of carotid artery)
Cerebral artery occlusion (blockage of blood vessel of brain by fat or clot)
Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Glossodynia (a burning or painful sensation in the tongue)
Haematoma (collection of blood outside the blood vessels)
Hepatitis (inflammation of the liver)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hyperkeratosis (thickening of the outer layer of the skin)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Intervertebral disc degeneration (spinal disc degeneration)

male:

Chronic kidney disease
Death
Cardiac failure congestive
Constipation
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Decreased appetite
Dizziness
Drug ineffective
Ear pain
Essential hypertension (primary hypertension)

What are the common drug interactions of Aciphex and Zestoretic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Back pain
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Chest pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Depression
Eye discharge
Eye swelling
Local swelling (swelling at the site of some application of substance or injury)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)

50-59:

Muscle cramp (painful sensation caused by muscle contraction)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nausea (feeling of having an urge to vomit)
Oral discomfort (pain or irritation in mouth)
Oral soft tissue disorder (oral soft tissue disease)
Osteoporosis (bones weak and more likely to break)
Seborrhoeic keratosis (noncancerous (benign) skin growths that some people develop as they age. they often appear on the back or chest)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Pain
Chronic kidney disease

60+:

Chronic kidney disease
Asthenia (weakness)
Spinal fracture (fracture in one of vertebrae)
Abdominal pain
Arthralgia (joint pain)
Back injury
Blood glucose increased
Cardiac arrest
Cardiac failure congestive
Carotid artery stenosis (narrowing of carotid artery)

What are the existing conditions these people have? *

Pain: 8 people, 22.86%
Osteoporosis (bones weak and more likely to break): 5 people, 14.29%
Joint Swelling: 4 people, 11.43%
Indigestion: 4 people, 11.43%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 11.43%
Gout (uric acid crystals building up in the body): 4 people, 11.43%
Diabetes: 3 people, 8.57%
Nausea (feeling of having an urge to vomit): 3 people, 8.57%
Constipation: 3 people, 8.57%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 8.57%

* Approximation only. Some reports may have incomplete information.

Do you take Aciphex and Zestoretic?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously