Actemra and Amaryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actemra (tocilizumab) and Amaryl (glimepiride). Common drug interactions include upper respiratory tract inflammation among females and myocardial infarction among males.

The phase IV clinical study analyzes what interactions people have when they take Actemra and Amaryl. It is created by eHealthMe based on reports of 100 people who take the same drugs from the FDA, and is updated regularly.

What is Actemra?

Actemra has active ingredients of tocilizumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 102,759 Actemra users. Check the latest studies of Actemra.

What is Amaryl?

Amaryl has active ingredients of glimepiride. It is often used in diabetes. eHealthMe is studying from 32,259 Amaryl users. Check the latest studies of Amaryl.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

100 people who take Actemra and Amaryl together, and have interactions are studied.

What are the common drug interactions of Actemra and Amaryl, by gender? *:

female:

Upper respiratory tract inflammation
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Conjunctivitis (pink eye)
Infusion related reaction
Liver disorder (liver diseases)
Tonsillitis (inflammation of tonsil)
Asthenia (weakness)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Cellulitis (infection under the skin)
Influenza

male:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pneumonia
Compression fracture (fracture due to pressure caused by injury)
Disuse syndrome (deterioration of body systems as a result of prescribed or unavoidable inactivity)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hypertriglyceridaemia (excess of triglycerides in the blood)
Paraparesis (partial paralysis of the lower limbs)
Rash generalised (rash on most of body parts)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Non-small cell lung cancer (type of epithelial lung cancer)

What are the common drug interactions of Actemra and Amaryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood pressure increased
Arthralgia (joint pain)
Arthropathy
Blood glucose increased
Bone disorder
Drug ineffective
Drug intolerance (drug sensitivity)
Fall
Fatigue (feeling of tiredness)
Femur fracture

50-59:

Joint swelling
Pain
Pain in extremity
Red blood cell sedimentation rate increased
Somnolence (a state of near-sleep, a strong desire for sleep)
Nausea (feeling of having an urge to vomit)
Weight decreased
Nephrolithiasis (calculi in the kidneys)
Arthralgia (joint pain)
Arthropathy

60+:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pneumonia
Confusional state
Drug ineffective
Fatigue (feeling of tiredness)
Hypersensitivity
Memory impairment
Oedema peripheral (superficial swelling)
Pain
Parotitis (inflammation of a parotid gland)

What are the existing conditions these people have? *

High Blood Pressure: 15 people, 15.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 10 people, 10.00%
Osteoporosis (bones weak and more likely to break): 8 people, 8.00%
High Blood Cholesterol: 6 people, 6.00%
Pain: 5 people, 5.00%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 5 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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