Actemra and Bumex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actemra (tocilizumab) and Bumex (bumetanide). Common drug interactions include upper limb fracture among females and angina pectoris among males.

The phase IV clinical study analyzes what interactions people have when they take Actemra and Bumex. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Actemra?

Actemra has active ingredients of tocilizumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 102,759 Actemra users. Check the latest studies of Actemra.

What is Bumex?

Bumex has active ingredients of bumetanide. It is often used in swelling. eHealthMe is studying from 9,210 Bumex users. Check the latest studies of Bumex.

On Jul, 06, 2026

15 people who take Actemra and Bumex together, and have interactions are studied.

What are the common drug interactions of Actemra and Bumex, by gender? *:

female:

Upper limb fracture
Anaemia (lack of blood)
Blood potassium decreased
Fall
Heart rate increased
Ill-defined disorder
Ligament sprain (ligament stretched)
Oedema peripheral (superficial swelling)
Osteoporosis (bones weak and more likely to break)
Thrombosis (formation of a blood clot inside a blood vessel)

male:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Atrioventricular block complete (heart block complete)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Cytokine storm (over-protective immune response that can actually be fatal)
Gamma-glutamyltransferase increased
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematuria (presence of blood in urine)
Hyperkalaemia (damage to or disease of the kidney)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)

What are the common drug interactions of Actemra and Bumex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Blood creatinine increased
Blood lactic acid increased
Blood urea increased
Bone marrow failure
Bradycardia (abnormally slow heart action)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Cytokine storm (over-protective immune response that can actually be fatal)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematuria (presence of blood in urine)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Alanine aminotransferase increased

60+:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Atrioventricular block complete (heart block complete)
Oedema peripheral (superficial swelling)
Osteoporosis (bones weak and more likely to break)
Thrombosis (formation of a blood clot inside a blood vessel)
Weight increased
Abdominal pain upper
Arthralgia (joint pain)
Diarrhoea
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Cardiac Failure Congestive: 4 people, 26.67%
Diabetes: 4 people, 26.67%
Dyspnea (difficult or laboured breathing): 3 people, 20.00%
High Blood Pressure: 3 people, 20.00%
Atrioventricular Block Complete (heart block complete): 2 people, 13.33%
Osteoporosis (bones weak and more likely to break): 2 people, 13.33%
Depression: 2 people, 13.33%
High Blood Cholesterol: 2 people, 13.33%
Erosive Oesophagitis (acid reflux disease can cause tissue damage in the oesophagus over time): 2 people, 13.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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