Actemra and Pentam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actemra (tocilizumab) and Pentam (pentamidine isethionate). Common drug interactions include septic shock among females and platelet count decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Actemra and Pentam. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Actemra?

Actemra has active ingredients of tocilizumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 102,759 Actemra users. Check the latest studies of Actemra.

What is Pentam?

Pentam has active ingredients of pentamidine isethionate. eHealthMe is studying from 5,686 Pentam users. Check the latest studies of Pentam.

On Jul, 28, 2026

21 people who take Actemra and Pentam together, and have interactions are studied.

What are the common drug interactions of Actemra and Pentam, by gender? *:

female:

Septic shock (shock due to blood infection)
Drug hypersensitivity
Immunodeficiency
Mouth ulceration (mouth ulcers)
Pneumonia
Fluid overload (too much fluid in the blood)
Impaired healing
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Abdominal pain
Acidosis (build-up of carbon dioxide in the blood)

male:

Platelet count decreased
Abdominal infection
Blood calcium decreased
Blood chloride increased
Blood creatinine decreased
Blood fibrinogen decreased
Blood glucose increased
Blood lactate dehydrogenase increased
Blood magnesium increased
Blood phosphorus decreased

What are the common drug interactions of Actemra and Pentam, by age (0-1 to 60+)? *:

0-1:

Abdominal infection
Activated partial thromboplastin time prolonged
Alanine aminotransferase increased
Ammonia decreased
Anaemia (lack of blood)
Anion gap increased
Aspartate aminotransferase increased
Blast cell count increased
Blood albumin decreased
Blood calcium decreased

2-9:

Abdominal pain
Drug eruption (adverse drug reaction of the skin)
Histiocytosis haematophagic
Platelet count decreased
Vomiting

10-19:

n/a

20-29:

Abdominal pain
Acidosis (build-up of carbon dioxide in the blood)
Aspartate aminotransferase increased
Death
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Drug hypersensitivity
Fluid overload (too much fluid in the blood)
Headache (pain in head)
Hypertension (high blood pressure)

30-39:

Disease progression

40-49:

Ascites (accumulation of fluid in the abdominal cavity)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Bacteraemia (presence of bacteria in the blood)
Blood bilirubin increased
Candida sepsis (candida in blood stream)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Fluid overload (too much fluid in the blood)
Lactic acidosis (low ph in body tissues)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Portal hypertension (increase in the blood pressure within a system of veins called the portal venous system)

50-59:

Sepsis (a severe blood infection that can lead to organ failure and death)
Drug hypersensitivity
Immunodeficiency
Mouth ulceration (mouth ulcers)
Pneumonia

60+:

Haematuria (presence of blood in urine)
Injection site reaction
Mycobacterial infection
Skin infection
Soft tissue infection
Tendonitis (a condition that causes pain and swelling of tendons)

What are the existing conditions these people have? *

Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 4 people, 19.05%
Allergic Rhinitis: 4 people, 19.05%
Cytokine Release Syndrome (immediate complication occurring with the use of anti-t cell antibody infusions): 3 people, 14.29%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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