Acth and Prolia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acth (corticotropin) and Prolia (denosumab). Common drug interactions include infusion site extravasation among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Acth and Prolia. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Acth?

Acth has active ingredients of corticotropin. eHealthMe is studying from 5,402 Acth users. Check the latest studies of Acth.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,389 Prolia users. Check the latest studies of Prolia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

25 people who take Acth and Prolia together, and have interactions are studied.

What are the common drug interactions of Acth and Prolia, by gender? *:

female:

Infusion site extravasation (flow of (blood or lymph) from infusion site)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Stress
Cystitis (inflammation of the wall of the bladder)
Headache (pain in head)
Urinary tract infection
Adverse event
Blood urine present
Dysphagia (a condition in which swallowing is difficult or painful)
Dysuria (painful or difficult urination)

male:

Death
Pancreatic carcinoma (pancreatic cancer)

What are the common drug interactions of Acth and Prolia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Death
Bladder neoplasm (bladder tumour)
Blood urine present
Cystitis (inflammation of the wall of the bladder)
Dysuria (painful or difficult urination)
Micturition urgency (urgency to pass the urine)
Nausea (feeling of having an urge to vomit)
Pancreatic carcinoma (pancreatic cancer)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Urinary tract infection

60+:

Asthenia (weakness)
Fatigue (feeling of tiredness)
Adverse event
Dysphagia (a condition in which swallowing is difficult or painful)
Memory impairment
Muscular weakness (muscle weakness)
Oesophageal disorder (disease of oesophagus)
Pain
Panic disorder
Uterine disorder

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 10 people, 40.00%
Gait Disturbance: 8 people, 32.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 24.00%
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 6 people, 24.00%
Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 2 people, 8.00%
Immunodeficiency Common Variable: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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