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Acthar and Arava drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acthar (corticotropin) and Arava (leflunomide). Common drug interactions include abdominal distension among females.

The phase IV clinical study analyzes what interactions people have when they take Acthar and Arava. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Acthar?

Acthar has active ingredients of corticotropin. eHealthMe is studying from 4,948 Acthar users. Check the latest studies of Acthar.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

On Aug, 11, 2026

15 people who take Acthar and Arava together, and have interactions are studied.

Acthar and Arava drug interactions.

What are the common drug interactions of Acthar and Arava, by gender? *:

female:

  1. Abdominal distension
  2. Blood glucose increased
  3. Rash
  4. Escherichia sepsis (bacterial infection by escherichia coli)
  5. Sinusitis (inflammation of sinus)
  6. Urticaria (rash of round, red welts on the skin that itch intensely)
  7. Headache (pain in head)
  8. Infusion related reaction
  9. Lung infection
  10. Aphasia (damage to the parts of the brain that control language)

male:

n/a

What are the common drug interactions of Acthar and Arava, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Abdominal distension
  2. Blood glucose increased
  3. Rash
  4. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  5. Blood pressure increased
  6. Drug eruption (adverse drug reaction of the skin)
  7. Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
  8. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  9. Cystitis (inflammation of the wall of the bladder)
  10. Diarrhoea

What are the existing conditions these people have? *

  1. Urinary Tract Infection: 6 people, 40.00%
  2. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 2 people, 13.33%
  3. Swelling: 2 people, 13.33%
  4. Diarrhea: 2 people, 13.33%
  5. Abdominal Distension: 2 people, 13.33%
  6. Nephrotic Syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema): 1 person, 6.67%
  7. Joint Pain: 1 person, 6.67%
  8. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 6.67%
  9. High Blood Cholesterol: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Acthar and Arava?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Acthar and Arava:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Acthar:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Arava:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Acthar and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Arava and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on corticotropin and leflunomide (the active ingredients of Acthar and Arava, respectively), and Acthar and Arava (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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