Acthar and Prilosec drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acthar (corticotropin) and Prilosec (omeprazole). Common drug interactions include joint injury among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Acthar and Prilosec. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Acthar?

Acthar has active ingredients of corticotropin. eHealthMe is studying from 4,948 Acthar users. Check the latest studies of Acthar.

What is Prilosec?

Prilosec has active ingredients of omeprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 175,285 Prilosec users. Check the latest studies of Prilosec.

On Jul, 28, 2026

51 people who take Acthar and Prilosec together, and have interactions are studied.

What are the common drug interactions of Acthar and Prilosec, by gender? *:

female:

Joint injury
Malaise (a feeling of general discomfort or uneasiness)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscle spasms (muscle contraction)
Oedema peripheral (superficial swelling)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pulmonary embolism (blockage of the main artery of the lung)
Pyrexia (fever)
Sinusitis (inflammation of sinus)
Sleep disorder

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Thyroid disorder (thyroid diseases)
Urinary tract infection
Abdominal pain
Ascites (accumulation of fluid in the abdominal cavity)
Delirium (wild excitement)
Diarrhoea
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)

What are the common drug interactions of Acthar and Prilosec, by age (0-1 to 60+)? *:

0-1:

Hypertension (high blood pressure)
Glaucoma (increased fluid pressure in the eye with vision loss)
Brain injury
Choreoathetosis (involuntary movement randomly from one part to another body part)
Irritability
Respiratory failure (inadequate gas exchange by the respiratory system)
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)

2-9:

n/a

10-19:

Abdominal pain
Ascites (accumulation of fluid in the abdominal cavity)
Diarrhoea
Fatigue (feeling of tiredness)
Fluid overload (too much fluid in the blood)
Gastroenteritis (inflammation of stomach and intestine)
Generalised oedema (swelling all over the body)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Oedema (fluid collection in tissue)

20-29:

Abdominal pain
Squamous cell carcinoma of the cervix (cervix cancer of a kind of epithelial cell)

30-39:

Chronic kidney disease
Hyperglycaemia (high blood sugar)
Oedema (fluid collection in tissue)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Thyroid disorder (thyroid diseases)
Arthralgia (joint pain)

40-49:

Asthenia (weakness)
Blood pressure increased
Palpitations (feelings or sensations that your heart is pounding or racing)
Tremor (trembling or shaking movements in one or more parts of your body)
Electrolyte imbalance
Headache (pain in head)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Urinary tract infection
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Syncope (loss of consciousness with an inability to maintain postural tone)

50-59:

Insomnia (sleeplessness)
Jugular vein thrombosis (clot in jugular vein)
Lethargy (tiredness)
Night sweats (sweating in night)
Pain in extremity
Peripheral swelling
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Skin tightness
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Tremor (trembling or shaking movements in one or more parts of your body)

60+:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Muscular weakness (muscle weakness)
Rash erythematous (redness of the skin)
Skin exfoliation (removal of the oldest dead skin cells)
Swelling
Weight increased
Asthenia (weakness)
Bacteraemia (presence of bacteria in the blood)
Blindness unilateral

What are the existing conditions these people have? *

Pain: 13 people, 25.49%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 11 people, 21.57%
High Blood Cholesterol: 11 people, 21.57%
High Blood Pressure: 9 people, 17.65%
Fluid Retention (an abnormal accumulation of fluid in the blood): 8 people, 15.69%
Renal Disorder (kidney disease): 8 people, 15.69%
Panic Disorder: 8 people, 15.69%
Bone Disorder: 5 people, 9.80%
Urine Analysis Abnormal: 4 people, 7.84%
Blood Pressure Abnormal: 4 people, 7.84%

* Approximation only. Some reports may have incomplete information.

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