Actifed and Contac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actifed (pseudoephedrine hydrochloride; triprolidine hydrochloride) and Contac (chlorpheniramine maleate; phenylpropanolamine hydrochloride). Common drug interactions include headache among females and cerebrovascular accident among males.

The phase IV clinical study analyzes what interactions people have when they take Actifed and Contac. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Actifed?

Actifed has active ingredients of pseudoephedrine hydrochloride; triprolidine hydrochloride. It is often used in allergies. eHealthMe is studying from 1,091 Actifed users. Check the latest studies of Actifed.

What is Contac?

Contac has active ingredients of chlorpheniramine maleate; phenylpropanolamine hydrochloride. eHealthMe is studying from 2,877 Contac users. Check the latest studies of Contac.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

12 people who take Actifed and Contac together, and have interactions are studied.

What are the common drug interactions of Actifed and Contac, by gender? *:

female:

Headache (pain in head)
Nervousness
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Hypotension (abnormally low blood pressure)
Blood pressure decreased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Injury
Memory impairment
Psychomotor seizures (complex partial seizures)
Syncope (loss of consciousness with an inability to maintain postural tone)

male:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Blood pressure increased
Disturbance in attention
Dyspnoea (difficult or laboured respiration)
Hemiparesis (weakness on one side of the body)
Hyperreflexia (overactive or over responsive reflexes)
Lacunar infarction (a type of stroke)
Asthenia (weakness)
Cough
Dizziness

What are the common drug interactions of Actifed and Contac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Headache (pain in head)
Hypotension (abnormally low blood pressure)
Nervousness
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Aggression
Carotid artery stenosis (narrowing of carotid artery)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Head injury
Psychomotor seizures (complex partial seizures)

20-29:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Memory impairment
Syncope (loss of consciousness with an inability to maintain postural tone)
Activities of daily living impaired
Anaemia (lack of blood)
Apraxia (disorder that affects a person's ability to organize the movements of the muscles used in speech)
Ataxia (loss of full control of bodily movements)
Blood alkaline phosphatase increased
Blood pressure decreased
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)

30-39:

Headache (pain in head)
Vomiting
Anxiety
Asthenia (weakness)
Cough
Dizziness
Dizziness (excl vertigo)
Injury
Pain
Weakness

40-49:

n/a

50-59:

Aphasia (damage to the parts of the brain that control language)
Diabetes mellitus non-insulin-dependent
Disturbance in attention
Dyspnoea (difficult or laboured respiration)
Hemiparesis (weakness on one side of the body)
Hyperreflexia (overactive or over responsive reflexes)
Lacunar infarction (a type of stroke)

60+:

n/a

What are the existing conditions these people have? *

Nasopharyngitis (inflammation of the nasopharynx): 5 people, 41.67%
Weight Decreased: 2 people, 16.67%
Sinus Congestion (blockage of sinus): 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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