Actigall and Duragesic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actigall (ursodiol) and Duragesic (fentanyl). Common drug interactions include nausea among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Actigall and Duragesic. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Actigall?

Actigall has active ingredients of ursodiol. It is often used in gallstones. eHealthMe is studying from 2,162 Actigall users. Check the latest studies of Actigall.

What is Duragesic?

Duragesic has active ingredients of fentanyl. eHealthMe is studying from 66,597 Duragesic users. Check the latest studies of Duragesic.

On Jul, 12, 2026

27 people who take Actigall and Duragesic together, and have interactions are studied.

Actigall and Duragesic drug interactions.

What are the common drug interactions of Actigall and Duragesic, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Fatigue (feeling of tiredness)
Hot flush (sudden feelings of heat)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Asthenia (weakness)

male:

Arthralgia (joint pain)
Deformity (disfigurement)
Joint range of motion decreased (disease of joint movement)
Mobility decreased (ability to move is reduced)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema (fluid collection in tissue)
Oedema peripheral (superficial swelling)
Pain
Pain in extremity

What are the common drug interactions of Actigall and Duragesic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hepatic failure (liver failure)

30-39:

n/a

40-49:

Abdominal pain
Application site irritation
Application site reaction
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Dehydration (dryness resulting from the removal of water)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Erythema (redness of the skin)
Haemorrhage (bleeding)
Intestinal obstruction

50-59:

Arthralgia (joint pain)
Deformity (disfigurement)
Erythema (redness of the skin)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Gait disturbance
General physical health deterioration (weak health status)
Hyperkeratosis (thickening of the outer layer of the skin)
Hypoaesthesia (reduced sense of touch or sensation)
Joint contracture (a permanent shortening of a muscle or joint)
Joint range of motion decreased (disease of joint movement)

60+:

Nausea (feeling of having an urge to vomit)
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Death
Sepsis (a severe blood infection that can lead to organ failure and death)
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Chronic hepatic failure (long lasting liver failure)
Confusional state
Constipation
Decreased appetite

What are the existing conditions these people have? *

Pain: 10 people, 37.04%
Back Pain: 7 people, 25.93%
Hepatic Steatosis (fatty liver disease): 5 people, 18.52%
Gastric Disorder (disease of stomach): 5 people, 18.52%
Cholangiocarcinoma (a cancer that forms glands or secretes significant amounts of mucins): 5 people, 18.52%
Nuclear Magnetic Resonance Imaging Brain: 3 people, 11.11%
Cough: 3 people, 11.11%
Nausea (feeling of having an urge to vomit): 2 people, 7.41%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 7.41%
Gallbladder Disorder: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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