Actigall and Ibu drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actigall (ursodiol) and Ibu (ibuprofen). Common drug interactions include pulmonary hypertension among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Actigall and Ibu. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Actigall?

Actigall has active ingredients of ursodiol. It is often used in gallstones. eHealthMe is studying from 2,162 Actigall users. Check the latest studies of Actigall.

What is Ibu?

Ibu has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 246,531 Ibu users. Check the latest studies of Ibu.

On Jul, 29, 2026

45 people who take Actigall and Ibu together, and have interactions are studied.

What are the common drug interactions of Actigall and Ibu, by gender? *:

female:

Pulmonary hypertension (increase in blood pressure in the lung artery)
Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue)
Sensation of foreign body
Suicidal ideation
Vocal cord polyp
Vomiting
Abdominal pain lower
Abdominal pain upper
Abscess (pus)
Adjustment disorder

male:

Asthenia (weakness)
Hypophagia (reduced food intake)
Emotional distress
Faecal volume decreased
Faeces discoloured
Fatigue (feeling of tiredness)
Gallbladder disorder
Hepatic fibrosis (scarring process that represents the liver's response to injury)
Hepatic necrosis (large portions of liver die off due to severe liver disease)
Hepatic steatosis (fatty liver disease)

What are the common drug interactions of Actigall and Ibu, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abdominal pain
Cholangitis (infection of the bile duct)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Diarrhoea
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Fungaemia (fungi circulate in the blood)
Gallbladder disorder
Groin pain
Kidney enlargement
Liver disorder (liver diseases)

10-19:

Ependymoma malignant (cancer in the brain)
Febrile convulsion (a convulsion associated with a significant rise in body temperature)
Lower respiratory tract infection viral
Secondary immunodeficiency (lack of immunity due to some disease)
Abdominal pain
Gastroenteritis (inflammation of stomach and intestine)

20-29:

Hepatobiliary disease (diseases affect the liver and/or biliary tract)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Infection
Injury
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Post-traumatic stress disorder
Thrombosis (formation of a blood clot inside a blood vessel)

30-39:

Cholecystitis chronic (long lasting infection of gallbladder)
Abdominal pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Antepartum haemorrhage (bleeding from the vagina during pregnancy from the 24th week)
Anxiety
Blood alkaline phosphatase increased
Budd-chiari syndrome (problem that results from blood clotting in the veins flowing out of the liver (hepatic veins))
Burning sensation
Chest pain
Cholecystitis (infection of gallbladder)

40-49:

Abdominal pain upper
Anxiety
Asthenia (weakness)
Blood albumin decreased
Blood bilirubin increased
Blood chloride decreased
Blood glucose increased
Cholangitis (infection of the bile duct)
Chronic hepatitis (long lasting inflammation of liver)
Emotional distress

50-59:

Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteoporosis (bones weak and more likely to break)
Pain in extremity
Pelvic inflammatory disease
Pneumonia
Postnasal drip
Proteinuria (presence of protein in the urine)
Pulmonary function test nos decreased
Pyelonephritis (inflammation of kidney caused by bacteria)
Rectal bleeding (bleeding from rectum)

60+:

Chest pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dizziness
Dyskinesia (abnormality or impairment of voluntary movement)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Ear pain
Emotional disorder
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Depression: 8 people, 17.78%
Cystic Fibrosis (disease of the secretary glands): 8 people, 17.78%
Primary Myelofibrosis (primary disorder of the bone marrow): 6 people, 13.33%
Insomnia (sleeplessness): 6 people, 13.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 13.33%
High Blood Pressure: 5 people, 11.11%
Diarrhea: 5 people, 11.11%
Sleep Disorder: 4 people, 8.89%
Nausea (feeling of having an urge to vomit): 4 people, 8.89%
Headache (pain in head): 4 people, 8.89%

* Approximation only. Some reports may have incomplete information.

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