Actigall and Medrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actigall (ursodiol) and Medrol (methylprednisolone). Common drug interactions include lower limb fracture among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Actigall and Medrol. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Actigall?

Actigall has active ingredients of ursodiol. It is often used in gallstones. eHealthMe is studying from 2,162 Actigall users. Check the latest studies of Actigall.

What is Medrol?

Medrol has active ingredients of methylprednisolone. It is often used in rheumatoid arthritis. eHealthMe is studying from 24,443 Medrol users. Check the latest studies of Medrol.

On Aug, 02, 2026

51 people who take Actigall and Medrol together, and have interactions are studied.

What are the common drug interactions of Actigall and Medrol, by gender? *:

female:

Lower limb fracture
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteoporosis (bones weak and more likely to break)
Influenza like illness
Headache (pain in head)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Back pain
Chronic kidney disease
Cystitis (inflammation of the wall of the bladder)

male:

Depression
Ankle fracture
White blood cell count decreased
Dysphagia (a condition in which swallowing is difficult or painful)
Oedema peripheral (superficial swelling)
Colon cancer
Cough
Drug ineffective
Increased upper airway secretion
Joint dislocation (a joint position is changed from normal position)

What are the common drug interactions of Actigall and Medrol, by age (0-1 to 60+)? *:

0-1:

Abdominal pain upper
Constipation
Faecaloma (hard mass of fecal matter)
Hepatic mass
Rash
Rash scaly

2-9:

n/a

10-19:

n/a

20-29:

Leukopenia (less number of white blood cells in blood)
Abdominal pain
Ascites (accumulation of fluid in the abdominal cavity)
Diarrhoea
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Renal failure (kidney dysfunction)
Respiratory distress (difficulty in breathing)
Respiratory failure (inadequate gas exchange by the respiratory system)

30-39:

Haemoglobin decreased
White blood cell count decreased
Blood albumin decreased
Blood lactate dehydrogenase increased
Blood urea increased
Haematocrit decreased
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pericardial effusion (fluid around the heart)
Vasospasm (sudden constriction of a blood vessel, reducing its diameter and flow rate)
Ventricular hypertrophy (enlargement of ventricles (lower chambers) in the heart)

40-49:

Platelet count decreased
Pyrexia (fever)
Respiratory tract infection
Vomiting
Abdominal mass (localized enlargement or swelling in the human abdomen)
Abdominal pain
Anaemia (lack of blood)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Blood lactate dehydrogenase increased
Constipation

50-59:

Depression
Ankle fracture
Cellulitis (infection under the skin)
Fall
Lower limb fracture
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteoporosis (bones weak and more likely to break)
Pain
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Joint effusion (presence of extra fluid in joint covering)

60+:

Cardiac arrest
Chronic lymphocytic leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell))
Chronic lymphocytic leukaemia recurrent (repeated cancer of blood cells known as lymphocytes)
Disease recurrence
Dysphonia (speech disorder attributable to a disorder of phonation)
Hepatic enzyme increased
Lymphadenopathy (disease or enlargement of lymph nodes)
Platelet count decreased
Pneumonia
Urinary tract infection

What are the existing conditions these people have? *

Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 10 people, 19.61%
Insomnia (sleeplessness): 5 people, 9.80%
Nausea And Vomiting: 4 people, 7.84%
Nausea (feeling of having an urge to vomit): 4 people, 7.84%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 4 people, 7.84%
White Blood Cell Disorder: 3 people, 5.88%
Sleep Disorder: 3 people, 5.88%
Joint Swelling: 3 people, 5.88%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 3 people, 5.88%
High Blood Pressure: 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Actigall and Medrol?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously