Actigall and Opsumit drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actigall (ursodiol) and Opsumit (macitentan). Common drug interactions include hypervolaemia among females and mycobacterium abscessus infection among males.

The phase IV clinical study analyzes what interactions people have when they take Actigall and Opsumit. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Actigall?

Actigall has active ingredients of ursodiol. It is often used in gallstones. eHealthMe is studying from 2,162 Actigall users. Check the latest studies of Actigall.

What is Opsumit?

Opsumit has active ingredients of macitentan. eHealthMe is studying from 67,926 Opsumit users. Check the latest studies of Opsumit.

On Jul, 17, 2026

19 people who take Actigall and Opsumit together, and have interactions are studied.

What are the common drug interactions of Actigall and Opsumit, by gender? *:

female:

Hypervolaemia (abnormally increased volume of blood)
Portal hypertensive gastropathy (changes in the mucosa of the stomach in patients with portal hypertension;)
Skin ulcer
Surgery
Varices oesophageal (enlarged and swollen veins at the bottom of the oesophagus, near the stomach)
Wound infection pseudomonas
Ammonia increased
Compression fracture (fracture due to pressure caused by injury)
Haemorrhage (bleeding)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

male:

Mycobacterium abscessus infection (rapid growing bacterial infection)
Pulmonary hypertension (increase in blood pressure in the lung artery)

What are the common drug interactions of Actigall and Opsumit, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Back pain
Blood bilirubin increased
Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
Gastrointestinal erosion (gradual destruction of gastrointestinal tract because of the inflamed mucous membrane lining the stomach)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hypervolaemia (abnormally increased volume of blood)
Portal hypertensive gastropathy (changes in the mucosa of the stomach in patients with portal hypertension;)
Pulmonary oedema (fluid accumulation in the lungs)
Skin ulcer

50-59:

Blindness transient (sudden loss of vision)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Influenza
Psoriasis (immune-mediated disease that affects the skin)
Rectal haemorrhage (bleeding from anus)

60+:

Death
Liver disorder (liver diseases)
Pulmonary oedema (fluid accumulation in the lungs)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 15 people, 78.95%
Oedema Peripheral (superficial swelling): 11 people, 57.89%
Thrombosis (formation of a blood clot inside a blood vessel): 4 people, 21.05%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 4 people, 21.05%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 1 person, 5.26%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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