Actigall and Soliris drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actigall (ursodiol) and Soliris (eculizumab). Common drug interactions include drug ineffective among females.

The phase IV clinical study analyzes what interactions people have when they take Actigall and Soliris. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Actigall?

Actigall has active ingredients of ursodiol. It is often used in gallstones. eHealthMe is studying from 2,162 Actigall users. Check the latest studies of Actigall.

What is Soliris?

Soliris has active ingredients of eculizumab. It is often used in paroxysmal nocturnal hemoglobinuria (pnh). eHealthMe is studying from 58,821 Soliris users. Check the latest studies of Soliris.

On Jul, 12, 2026

14 people who take Actigall and Soliris together, and have interactions are studied.

What are the common drug interactions of Actigall and Soliris, by gender? *:

female:

Drug ineffective
Renal failure acute (rapid kidney dysfunction)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Post procedural haemorrhage (post procedural bleeding)
Splenomegaly (enlargement of spleen)
Staphylococcal infection (an infection with staphylococcus bacteria)
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Acute myocardial infarction (acute heart attack)
Asthenia (weakness)
Blood lactate dehydrogenase increased

male:

n/a

What are the common drug interactions of Actigall and Soliris, by age (0-1 to 60+)? *:

0-1:

Erythema multiforme (a type of hypersensitivity reaction)

2-9:

n/a

10-19:

n/a

20-29:

Gastrointestinal fungal infection
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Intestinal ulcer
Oral fungal infection
Rectal haemorrhage (bleeding from anus)

30-39:

Blood creatinine increased
Blood lactate dehydrogenase increased
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Hepatic enzyme increased
Nausea (feeling of having an urge to vomit)
Abdominal pain upper
Acute respiratory distress syndrome
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dizziness
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)

40-49:

n/a

50-59:

n/a

60+:

Drug ineffective
Abscess (pus)
Renal failure acute (rapid kidney dysfunction)
Splenomegaly (enlargement of spleen)
Staphylococcal infection (an infection with staphylococcus bacteria)
Acute myocardial infarction (acute heart attack)
Asthenia (weakness)
Cachexia (loss of weight)
Depression
Fall

What are the existing conditions these people have? *

Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 11 people, 78.57%
Liver Disorder (liver diseases): 3 people, 21.43%
Heart Rate Increased: 3 people, 21.43%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 2 people, 14.29%
Urinary Tract Infection: 1 person, 7.14%
Pain: 1 person, 7.14%
Nausea (feeling of having an urge to vomit): 1 person, 7.14%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 1 person, 7.14%
Insomnia (sleeplessness): 1 person, 7.14%
High Blood Pressure: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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