Actiq and Loraz drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actiq (fentanyl citrate) and Loraz (lorazepam). Common drug interactions include drug withdrawal syndrome among females and pain in extremity among males.

The phase IV clinical study analyzes what interactions people have when they take Actiq and Loraz. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Actiq?

Actiq has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 27,583 Actiq users. Check the latest studies of Actiq.

What is Loraz?

Loraz has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,695 Loraz users. Check the latest studies of Loraz.

On Aug, 05, 2026

74 people who take Actiq and Loraz together, and have interactions are studied.

What are the common drug interactions of Actiq and Loraz, by gender? *:

female:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Fatigue (feeling of tiredness)
Hypoaesthesia (reduced sense of touch or sensation)
Pneumonia
Tooth abscess (pus formation in tooth)
Abnormal behaviour
Alopecia (absence of hair from areas of the body)
Anuria (failure of the kidneys to produce urine)
Cachexia (loss of weight)
Constipation

male:

Pain in extremity
Bone disorder
Pneumonia
Tooth abscess (pus formation in tooth)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Pulmonary embolism (blockage of the main artery of the lung)
Thrombosis (formation of a blood clot inside a blood vessel)
Anaemia (lack of blood)
Dental caries
Actinomycosis (infection that causes sores, or abscesses)

What are the common drug interactions of Actiq and Loraz, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain upper
Blood pressure increased
Chest pain
Heart rate increased
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Vomiting

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Decreased appetite
Drug dependence
Fall
Headache (pain in head)
Lethargy (tiredness)
Ligament sprain (ligament stretched)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Migraine (headache)
Nausea (feeling of having an urge to vomit)

40-49:

Pain in extremity
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone disorder
Colon cancer metastatic (cancer of colon spreads to other part of body)
Compression fracture (fracture due to pressure caused by injury)
Constipation
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Haematuria (presence of blood in urine)
Hypertension (high blood pressure)

50-59:

Impaired healing
Incisional drainage
Infection
Inflammation
Malignant pleural effusion (a condition in which cancer causes an abnormal amount of fluid to collect between the thin layers of tissue lining of lung)
Metastatic neoplasm (spreadable cancer tumour)
Oedema peripheral (superficial swelling)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteomyelitis (infection of bone)
Pain in extremity

60+:

Back pain
Nausea (feeling of having an urge to vomit)
Chest pain
Confusional state
Constipation
Death
Decreased appetite
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Diarrhoea
Disease progression

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 9 people, 12.16%
Metastases To Bone (cancer spreads to bone): 9 people, 12.16%
High Blood Pressure: 5 people, 6.76%
Cancer Pain: 5 people, 6.76%

* Approximation only. Some reports may have incomplete information.

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