Activase and Emla drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Activase (alteplase) and Emla (lidocaine; prilocaine). Common drug interactions include abdominal discomfort among females and alcohol abuse among males.

The phase IV clinical study analyzes what interactions people have when they take Activase and Emla. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Activase?

Activase has active ingredients of alteplase. eHealthMe is studying from 7,526 Activase users. Check the latest studies of Activase.

What is Emla?

Emla has active ingredients of lidocaine; prilocaine. eHealthMe is studying from 5,276 Emla users. Check the latest studies of Emla.

On Jul, 13, 2026

24 people who take Activase and Emla together, and have interactions are studied.

What are the common drug interactions of Activase and Emla, by gender? *:

female:

Abdominal discomfort
Headache (pain in head)
Thrombocytopenia (decrease of platelets in blood)
Blood calcium decreased
Constipation
Decreased appetite
Dry skin
Dysgeusia (disorder of the sense of taste)
Dyspepsia (indigestion)
Emotional distress

male:

Alcohol abuse
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Failure to thrive (inadequate weight gain and physical growth in children)
Hyperchloraemia (an excess of chlorides in the blood)
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Hypokalaemia (low potassium)
Hypophagia (reduced food intake)
Hypotension (abnormally low blood pressure)

What are the common drug interactions of Activase and Emla, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Arrhythmia (irregular heartbeat)
Dyspnoea (difficult or laboured respiration)
Hypotension (abnormally low blood pressure)
Right ventricular failure (right half of the heart fails to work)

20-29:

n/a

30-39:

Febrile neutropenia (fever with reduced white blood cells)
Neutropenic colitis (inflammation of the cecum, often with involvement of the ascending colon and ileum, a life threatening condition)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Respiratory failure (inadequate gas exchange by the respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)

40-49:

Alcohol abuse
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Lung abscess (pus in lungs)

50-59:

Hypokalaemia (low potassium)
Plasma cell myeloma (cancer that begins in plasma cells)

60+:

Thrombocytopenia (decrease of platelets in blood)
Blood calcium decreased
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Heart rate increased
Leukaemia recurrent (repeat cancer of bone marrow or blood cells)
Nausea (feeling of having an urge to vomit)
Oesophageal stenosis (narrowing of oesophagus)
Peripheral swelling
Rectal haemorrhage (bleeding from anus)
Stomatitis (inflammation of mucous membrane of mouth)

What are the existing conditions these people have? *

Pain: 9 people, 37.50%
Ovarian Cancer (cancer of ovary): 8 people, 33.33%
Nausea (feeling of having an urge to vomit): 5 people, 20.83%
Constipation: 5 people, 20.83%
Nausea And Vomiting: 4 people, 16.67%
Insomnia (sleeplessness): 4 people, 16.67%
Indigestion: 3 people, 12.50%
High Blood Pressure: 3 people, 12.50%
Stress And Anxiety: 2 people, 8.33%
Fungal Infection: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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