Activase and Glucotrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Activase (alteplase) and Glucotrol (glipizide). Common drug interactions include angioedema among females and cardiomegaly among males.

The phase IV clinical study analyzes what interactions people have when they take Activase and Glucotrol. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Activase?

Activase has active ingredients of alteplase. eHealthMe is studying from 7,526 Activase users. Check the latest studies of Activase.

What is Glucotrol?

Glucotrol has active ingredients of glipizide. It is often used in diabetes. eHealthMe is studying from 20,322 Glucotrol users. Check the latest studies of Glucotrol.

On Jul, 20, 2026

14 people who take Activase and Glucotrol together, and have interactions are studied.

Activase and Glucotrol drug interactions.

What are the common drug interactions of Activase and Glucotrol, by gender? *:

female:

Angioedema (rapid swelling of the dermis)
Chest pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Flushing (the warm, red condition of human skin)
Haematocrit decreased
Haemoglobin decreased
Hypovolaemia (a decreased volume of circulating blood in the body)
Intestinal obstruction
Neutropenia (an abnormally low number of neutrophils)
Pericardial effusion (fluid around the heart)

male:

Cardiomegaly (increased size of heart than normal)
Aggression
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiac failure congestive
Cataract (clouding of the lens inside the eye)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest discomfort
Chorea (abnormal involuntary movement disorder)
Depression

What are the common drug interactions of Activase and Glucotrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cardiac ventricular thrombosis (blood clot in ventricle)
Cardiomegaly (increased size of heart than normal)
Hyperglycaemia (high blood sugar)
Pleuritic pain
Chest pain
Vomiting

50-59:

Aggression
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Flushing (the warm, red condition of human skin)
Haematocrit decreased
Haemoglobin decreased
Hypovolaemia (a decreased volume of circulating blood in the body)
Intestinal obstruction
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Neutropenia (an abnormally low number of neutrophils)
Pericardial effusion (fluid around the heart)

60+:

Angioedema (rapid swelling of the dermis)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Areflexia (absence of a reflex)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiac failure congestive
Cardiomegaly (increased size of heart than normal)
Cataract (clouding of the lens inside the eye)
Chest discomfort
Chorea (abnormal involuntary movement disorder)

What are the existing conditions these people have? *

Acute Myocardial Infarction (acute heart attack): 4 people, 28.57%
Ischaemic Stroke (stroke; caused by an interruption in the flow of blood to the brain): 2 people, 14.29%
Breast Cancer Metastatic: 2 people, 14.29%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 7.14%
Oesophagitis (inflammation of oesophagus): 1 person, 7.14%
Migraine (headache): 1 person, 7.14%
Fever: 1 person, 7.14%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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