Activase and Insulin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Activase (alteplase) and Insulin (insulin pork). Common drug interactions include gastrointestinal haemorrhage among females and chest pain among males.

The phase IV clinical study analyzes what interactions people have when they take Activase and Insulin. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Activase?

Activase has active ingredients of alteplase. eHealthMe is studying from 7,526 Activase users. Check the latest studies of Activase.

What is Insulin?

Insulin has active ingredients of insulin pork. It is often used in diabetes. eHealthMe is studying from 50,203 Insulin users. Check the latest studies of Insulin.

On Aug, 08, 2026

34 people who take Activase and Insulin together, and have interactions are studied.

What are the common drug interactions of Activase and Insulin, by gender? *:

female:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Hypoxia (low oxygen in tissues)
Injection site infection
International normalised ratio increased
Irritability
Laryngitis (inflammation of the larynx)
Lethargy (tiredness)
Leukocytosis (increased white blood cells)

male:

Chest pain
Haemorrhagic transformation stroke (haemorrhages develop inside areas of ischemia)
Skin fissures (a crack in the skin)
Abdominal distension
Abdominal pain upper
Anaemia (lack of blood)
Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)
Back pain
Blood cholesterol increased
Blood glucose increased

What are the common drug interactions of Activase and Insulin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood potassium decreased

30-39:

Blood pressure increased
Chest pain
Dyspnoea (difficult or laboured respiration)

40-49:

Chest pain
Dyspepsia (indigestion)
Abdominal pain upper
Blood glucose increased
Malaise (a feeling of general discomfort or uneasiness)
Gingival bleeding (bleeding gums)
Hyperhidrosis (abnormally increased sweating)
Abdominal distension
Anaemia (lack of blood)
Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)

50-59:

Chest pain
Dyspnoea (difficult or laboured respiration)
Sinus bradycardia (an unusually slow heartbeat due to heart disease)
Skin fissures (a crack in the skin)
Angioedema (rapid swelling of the dermis)
Atrioventricular block (heart block)
Cardiac arrest
Cardiogenic shock (inadequate circulation of blood)
Drooling (drop saliva uncontrollably from the mouth)
Dysphonia (speech disorder attributable to a disorder of phonation)

60+:

Haemorrhagic transformation stroke (haemorrhages develop inside areas of ischemia)
Hyperhidrosis (abnormally increased sweating)
Hypersensitivity
Bradycardia (abnormally slow heart action)
Bronchial secretion retention
Cardiac failure congestive
Cerebral atrophy (decrement in size of brain)
Cerebral haemorrhage (bleeding within the brain)
Cerebral hypoperfusion (a condition in which the brain doesn't get enough blood)
Cough

What are the existing conditions these people have? *

Acute Myocardial Infarction (acute heart attack): 11 people, 32.35%
High Blood Pressure: 6 people, 17.65%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 3 people, 8.82%
Pain: 2 people, 5.88%
Device Occlusion: 2 people, 5.88%
Dementia (madness): 2 people, 5.88%
Constipation: 2 people, 5.88%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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