Activase and Posaconazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Activase (alteplase) and Posaconazole (posaconazole). Common drug interactions include aspartate aminotransferase increased among females and bronchopulmonary aspergillosis among males.

The phase IV clinical study analyzes what interactions people have when they take Activase and Posaconazole. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Activase?

Activase has active ingredients of alteplase. eHealthMe is studying from 7,526 Activase users. Check the latest studies of Activase.

What is Posaconazole?

Posaconazole has active ingredients of posaconazole. eHealthMe is studying from 9,475 Posaconazole users. Check the latest studies of Posaconazole.

On Jul, 14, 2026

12 people who take Activase and Posaconazole together, and have interactions are studied.

Activase and Posaconazole drug interactions.

What are the common drug interactions of Activase and Posaconazole, by gender? *:

female:

Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Hyperbilirubinaemia (excess of bilirubin in the blood)
Neutropenic colitis (inflammation of the cecum, often with involvement of the ascending colon and ileum, a life threatening condition)
Sepsis (a severe blood infection that can lead to organ failure and death)
Leukaemia recurrent (repeat cancer of bone marrow or blood cells)
Asthenia (weakness)
Diarrhoea
Epistaxis (bleed from the nose)
Mouth ulceration (mouth ulcers)

male:

Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Enterococcal bacteraemia (presence of bacteria lactic acid in the blood)
Febrile neutropenia (fever with reduced white blood cells)
Enterococcal infection
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back disorder
Enterococcal sepsis
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)

What are the common drug interactions of Activase and Posaconazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Acute respiratory distress syndrome
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Hyperbilirubinaemia (excess of bilirubin in the blood)
Neutropenic colitis (inflammation of the cecum, often with involvement of the ascending colon and ileum, a life threatening condition)
Sepsis (a severe blood infection that can lead to organ failure and death)

50-59:

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)

60+:

Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Enterococcal bacteraemia (presence of bacteria lactic acid in the blood)
Rash
Somnolence (a state of near-sleep, a strong desire for sleep)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Disease recurrence
Enterococcal sepsis
Febrile neutropenia (fever with reduced white blood cells)
Enterococcal infection
Leukaemia recurrent (repeat cancer of bone marrow or blood cells)

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 7 people, 58.33%
Febrile Neutropenia (fever with reduced white blood cells): 5 people, 41.67%
Nausea (feeling of having an urge to vomit): 5 people, 41.67%
Insomnia (sleeplessness): 4 people, 33.33%
Electrolyte Imbalance: 3 people, 25.00%
Nausea And Vomiting: 3 people, 25.00%
High Blood Pressure: 3 people, 25.00%
Fungal Infection: 3 people, 25.00%
Pain: 3 people, 25.00%
Constipation: 3 people, 25.00%

* Approximation only. Some reports may have incomplete information.

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